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Disturbed Flow, Endothelial Reprograming, and Atherosclerosis – Lessons from Single-Cell Genomics Study, with Professor Hanjoong Jo, Emory University and Georgia Tech

Image: Professor Hanjoong Jo, Emory University
Professor Hanjoong Jo, Emory University

Date: 5 May 2021   Time: 15:00 - 16:00

This week's seminar in MS Teams is entitled 'Disturbed Flow, Endothelial Reprograming, and Atherosclerosis - Lessons from Single-Cell Genomics Study'. We are delighted to welcome Professor Hanjoong Jo who is Coulter Distinguished Chair Professor and Associate Chair for Emory Biomedical Engineering, in the Coulter Department of Biomedical Engineering, at Emory University and Georgia Tech.

Abstract: Atherosclerosis is the major underlying cause of myocardial infarction and stroke, and occurs preferentially in arterial regions exposed to disturbed flow (d-flow) by mechanisms involving broad changes in expression of coding and non-coding genes. Using the partial carotid ligation model of atherosclerosis in mice and gene array and "bulk" RNA sequencing studies, we revealed the roles of flow-sensitive genes and microRNAs in endothelial dysfunction and atherosclerosis. These results showed that targeting mechanosensitive genes and "athero-miRs" provide a new treatment paradigm in atherosclerosis. Recently, we carried out single cell RNAseq and ATACseq studies using the partial carotid ligation model of atherosclerosis. The single cell study results and additional validation studies revealed that d-flow reprograms endothelial cells to proatherogenic phenotypes, including EndMT and endothelial-to-immune cell-like transition. I will discuss the implications of these results in atherosclerosis.

Location:  online
Contact:  Prof Rob Krams
Email:  r.krams@qmul.ac.uk

Updated by: Colin J Rainey