Self-assembling peptide hydrogels for biomedical applications: from design to commercialisation, with Prof. Alberto Saiani, FRSC (The University of Manchester)
Date: 31 March 2021 Time: 15:00 - 16:00
This week we welcome Alberto Saiani, Professor of Molecular Materials Manchester Institute of Biotechnology. The link is here
'Self-assembling peptide hydrogels for biomedical applications: from design to commercialisation'
Prof. Alberto Saiani, FRSC (Department of Materials & Manchester Institute of Biotechnology, The University of Manchester)
Abstract: The use of non-covalent self-assembly has become a prominent strategy in material science offering practical routes for the construction of increasingly functional materials for a variety of applications ranging from electronic to biotechnology. A variety of molecular building blocks can be used for this purpose, one such block that has attracted considerable attention in the last 20 years is de-novo designed peptides. Our group work focusses on the development of a technological platform for the design of novel biofunctional hydrogels exploiting the self-assembly of so-called b-sheet forming peptides. These hydrogels can be easily functionalised using specific biological signals and can also be made responsive through the use of enzymatic catalysis and/or conjugation with responsive polymers. Through the fundamental understanding of the self-assembly and gelation processes of these peptides across length scales we have been able to design hydrogels with tailored properties for a range of applications from tissue engineering, cell culture and drug delivery to 3D bioprinting and biosensing. In this seminar I will discuss our group's journey from hydrogel biomolecular design to their potential use in biomedical applications with a particular focus on regenerative medicine. I will also discuss the past and current challenges encounter along the translational pathway of a work that stemmed from basic scientific interest and went all the way to commercialisation.
|Contact:||Prof Julien Gautrot|
Updated by: Colin J Rainey