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Quality by digital design and techno-economic modelling of RNA vaccine production for pandemic response, with Dr Zoltán Kis, Imperial College London

Image: Dr Zoltán Kis, Imperial College London
Dr Zoltán Kis, Imperial College London

Date: 14 April 2021   Time: 15:00 - 16:00

Quality by digital design and techno-economic modelling of RNA vaccine production for pandemic response -

Microsoft Teams meeting - Click here to join

Abstract: The RNA vaccine platform technology has been successfully used to develop Covid-19 vaccines at record speeds. However, the RNA vaccine production volumes and rates can be further increased, while reducing costs and maintaining consistently high product quality. To aid this, we perform quality by digital design (QbDD) and techno-economic modelling of the RNA vaccine production process. In the QbDD framework, first-principle or data-driven relationships are established between the critical process parameters (CPPs) of the production process and the critical quality attributes (CQAs) of the RNA vaccine product. The obtained models can be used for defining the design space and for advanced automation using model-predictive control. By combining the QbDD model with the RNA vaccine platform, vaccines and candidate vaccines can be developed and mass-produced faster against virtually any viral disease. Techno-economic modelling supports production process de-bottlenecking and identification of optimal RNA vaccine production process configurations for a rapid pandemic response.

Location:  MS Teams
Contact:  Prof Julien Gautrot
Email:  j.gautrot@qmul.ac.uk
Website:  https://www.imperial.ac.uk/people/z.kis10

Updated by: Colin J Rainey