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Materials Research Institute

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Professor Paul Anderson

Professor of Oral Biology

Department Institute of Dentistry
 Dental Physical Science, Francis Bancroft Building
Telephone +44 20 7882 5962
Email p.anderson@qmul.ac.uk
Homepage http://www.dentistry.qmul.ac.uk/staff/oral-bioengineering/profiles/professorpaulanderson.html

Research Keywords

chemistry of enamel and hydroxyapatite, diffusion processes in enamel

Research Interests

My main research area is the chemistry of enamel and hydroxyapatite in the context of de and remineralisation of enamel. Recently, I have developed research into the influence of salivary proteins on these processes, to study their role in enamel homeostasis. I have developed novel X-ray absorption microscopies to assist with these studies, and have also used these technologies to study diffusion processes in enamel, and the efficacy of treatments for dental hypersensitivity. I have been sponsored by the MRC, EPSRC, Wellcome, as well as RAB, and QMUL grants. I currently have several PhD students, and a Postdoctoral research assistant.

Key Publications

Cochrane NJ, Anderson P, Davis GR, Adams GG, Stacey MA and Reynolds EC (2012). An X-ray Microtomographic Study of Natural White-spot Enamel Lesions. Journal of Dental Research  vol. 91, (2) 185-191. 10.1177/0022034511429570

Shah S, Kosoric J, Hector MP and Anderson P (2011). An in vitro scanning microradiography study of the reduction in hydroxyapatite demineralization rate by statherin-like peptides as a function of increasing N-terminal length. Eur J Oral Sci  vol. 119 Suppl 1, 13-18. 10.1111/j.1600-0722.2011.00899.x

Kosoric J, Hector MP and Anderson P (2010). The influence of proteins on demineralization kinetics of hydroxyapatite aggregates. J Biomed Mater Res A  vol. 94A, (3) 972-977. 10.1002/jbm.a.32759

Santos O, Kosoric J, Hector MP, Anderson P and Lindh L (2008). Adsorption behavior of statherin and a statherin peptide onto hydroxyapatite and silica surfaces by in situ ellipsometry. J Colloid Interf Sci  vol. 318, (2) 175-182. 10.1016/j.jcis.2007.11.015

2018

Huang WT, Shahid S and Anderson P (2018). Validation of a real-time ISE methodology to quantify the influence of inhibitors of demineralization kinetics in vitro using a hydroxyapatite model system. Caries Research  vol. 52, (6) 598-603. 10.1159/000488597

Elsharkawy S, Al-Jawad M, Pantano MF, Tejeda-Montes E, Mehta K, Jamal H, Agarwal S, Shuturminska K, Rice A, Tarakina NV, Wilson RM, Bushby AJ, Alonso M, Rodriguez-Cabello JC, Barbieri E, Del Río Hernández A, Stevens MM, Pugno NM, Anderson P and Mata A (2018). Protein disorder-order interplay to guide the growth of hierarchical mineralized structures. Nat Commun  vol. 9, (1) 10.1038/s41467-018-04319-0

Sleibi A, Tappuni AR, Davis GR, Anderson P and Baysan A (2018). Comparison of efficacy of dental varnish containing fluoride either with CPP-ACP or bioglass on root caries: Ex vivo study. J Dent  vol. 73, 91-96. 10.1016/j.jdent.2018.04.009

2017

Kazmi S, ANDERSON P and LIVERSIDGE HM (2017). A radiographic study of pulp crown dimensions of the mandibular deciduous second molar. International Journal of Dentistry and Oral Health  vol. 4, (1)

Hassanali L, Wong FS, Lynch RJM and Anderson P (2017). A Novel Kinetic Method to Measure Apparent Solubility Product of Bulk Human Enamel. Frontiers Media  Front Physiol  vol. 8, 1-9. 10.3389/fphys.2017.00714

Shuturminska K, Tarakina NV, Azevedo HS, Bushby AJ, Mata A, Anderson P and Al-Jawad M (2017). Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology. Front Physiol  vol. 8, 368-368. 10.3389/fphys.2017.00368

TOMLINS PH, Aden A, Anderson P, Lynch JM and Burnett G (2017). Longitudinal correlation of 3D OCT to detect early stage erosion in bovine enamel. Optical Society of America  Biomedical Optics Express  vol. 8, (2) 954-973. 10.1364/BOE.8.000954

2015

Tan MHX, Hill RG and Anderson P (2015). Comparing the Air Abrasion Cutting Efficacy of Dentine Using a Fluoride-Containing Bioactive Glass versus an Alumina Abrasive: An In Vitro Study. Int J Dent  vol. 2015, 10.1155/2015/521901

Mohammed NR, Lynch RJM and Anderson P (2015). Inhibitory Effects of Zinc Ions on Enamel Demineralisation Kinetics in vitro. Caries Res  vol. 49, (6) 600-605. 10.1159/000441014

2014

Mohammed NR, Mneimne M, Hill RG, Al-Jawad M, Lynch RJM and Anderson P (2014). Physical chemical effects of zinc on in vitro enamel demineralization. J Dent  vol. 42, (9) 1096-1104. 10.1016/j.jdent.2014.04.014

Mohammed NR, Lynch RJM and Anderson P (2014). Effects of fluoride concentration on enamel demineralization kinetics in vitro. J Dent  vol. 42, (5) 613-618. 10.1016/j.jdent.2013.12.005

Shahid S, Hassan U, Billington RW, Hill RG and Anderson P (2014). Glass ionomer cements: effect of strontium substitution on esthetics, radiopacity and fluoride release. Dent Mater  vol. 30, (3) 308-313. 10.1016/j.dental.2013.12.003

Siddiqui S, Anderson P and Al-Jawad M (2014). Recovery of crystallographic texture in remineralized dental enamel. Plos One  vol. 9, (10) 10.1371/journal.pone.0108879

2013

Mohammed NR, Kent NW, Lynch RJM, Karpukhina N, Hill R and Anderson P (2013). Effects of fluoride on in vitro enamel demineralization analyzed by ??F MAS-NMR. Caries Res  vol. 47, (5) 421-428. 10.1159/000350171

2012

Cochrane NJ, Anderson P, Davis GR, Adams GG, Stacey MA and Reynolds EC (2012). An X-ray Microtomographic Study of Natural White-spot Enamel Lesions. Journal of Dental Research  vol. 91, (2) 185-191. 10.1177/0022034511429570

2011

Shah S, Kosoric J, Hector MP and Anderson P (2011). An in vitro scanning microradiography study of the reduction in hydroxyapatite demineralization rate by statherin-like peptides as a function of increasing N-terminal length. Eur J Oral Sci  vol. 119 Suppl 1, 13-18. 10.1111/j.1600-0722.2011.00899.x

2010

Kosoric J, Hector MP and Anderson P (2010). The influence of proteins on demineralization kinetics of hydroxyapatite aggregates. J Biomed Mater Res A  vol. 94A, (3) 972-977. 10.1002/jbm.a.32759

2009

Mishra S, Thomas HF, Fearne JM, Boyde A and Anderson P (2009). Comparison of demineralisation rates in pre- and postnatal enamel and at the neonatal line. Arch Oral Biol  vol. 54 Suppl 1, S101-S106. 10.1016/j.archoralbio.2008.09.013

2008

Kawabata M, Hector MP, Davis GR, Parkinson CR, Rees GD and Anderson P (2008). Diffusive transport within dentinal tubules: an X-ray microtomographic study. Arch Oral Biol  vol. 53, (8) 736-743. 10.1016/j.archoralbio.2008.03.012

Santos O, Kosoric J, Hector MP, Anderson P and Lindh L (2008). Adsorption behavior of statherin and a statherin peptide onto hydroxyapatite and silica surfaces by in situ ellipsometry. J Colloid Interf Sci  vol. 318, (2) 175-182. 10.1016/j.jcis.2007.11.015

2007

Kosoric J, Williams RAD, Hector MP and Anderson P (2007). A synthetic peptide based on a natural salivary protein reduces demineralisation in model systems for dental caries and erosion. Int J Pept Res Ther  vol. 13, (4) 497-503. 10.1007/s10989-007-9085-0

Bollet-Quivogne FRG, Anderson P, Dowker SEP and Elliott JC (2007). Demineralisation of permeable hydroxyapatite with alternating water and acidic buffer: Scanning microradiographic study of effect of switching period. Caries Res  vol. 41, (2) 152-160. 10.1159/000098050

2006

Anderson P, Ahmed Y, Patel MP, Davis GR and Braden M (2006). X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications. Materials Science and Technology  vol. 22, (9) 1094-1097. 10.1179/174328406X114180

Fabes J, Anderson P, Yanez-Munoz RJ, Thrasher A, Brennan C and Bolsover S (2006). Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. Eur J Neurosci  vol. 23, (7) 1721-1730. 10.1111/j.1460-9568.2006.04704.x

Potter K, Sweet DE, Anderson P, Davis GR, Isogai N, Asamura S, Kusuhara H and Landis WJ (2006). Non-destructive studies of tissue-engineered phalanges by magnetic resonance microscopy and X-ray microtomography. Bone  vol. 38, (3) 350-358. 10.1016/j.bone.2005.08.025

2005

Moreau P, Raulic M, P'ng KMY, Gannaway G, Anderson P, Gillin WP, Bushby AJ and Dunstan DJ (2005). Measurement of the size effect in the yield strength of nickel foils. Phil Mag Lett  vol. 85, (7) 339-343. 10.1080/09500830500071564

Bollet-Quivogne FRG, Anderson P, Dowker SEP and Elliott JC (2005). Scanning microradiographic study on the influence of diffusion in the external liquid on the rate of demineralization in hydroxyapatite aggregates. Eur J Oral Sci  vol. 113, (1) 53-59. 10.1111/j.1600-0722.2005.00188.x

2004

Wong FSL, Anderson P, Fan H and Davis GR (2004). X-ray microtomographic study of mineral concentration distribution in deciduous enamel. Arch Oral Biol  vol. 49, (11) 937-944. 10.1016/j.archoralbio.2004.05.011

Li L, Grønning LM, Anderson PO, Li S, Edvardsen K, Johnston J, Kioussis D, Shepherd PR and Wang P (2004). Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism. J Biol Chem  vol. 279, (33) 34107-34114. 10.1074/jbc.M312672200

Washburn NR, Weir M, Anderson P and Potter K (2004). Bone formation in polymeric scaffolds evaluated by proton magnetic resonance microscopy and X-ray microtomography. J Biomed Mater Res A  vol. 69A, (4) 738-747. 10.1002/jbm.a.30054

Fearne J, Anderson P and Davis GR (2004). 3D X-ray microscopic study of the extent of variations in enamel density in first permanent molars with idiopathic enamel hypomineralisation. Br Dent J  vol. 196, (10) 634-638. 10.1038/sj.bdj.4811282

Anderson P, Bollet-Quivogne FRG, Dowker SEP and Elliott JC (2004). Demineralization in enamel and hydroxyapatite aggregates at increasing ionic strengths. Arch Oral Biol  vol. 49, (3) 199-207. 10.1016/j.archoralbio.2003.10.001

2003

Anderson P, Sundstedt A, Li L, O'Neill EJ, Li S, Wraith DC and Wang P (2003). Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells. Int Immunol  vol. 15, (11) 1309-1317. 10.1093/intimm/dxg130

Justice I, Derby B, Davis G, Anderson P and Elliott J (2003). Characterisation of void and reinforcement distributions in a metal matrix composite by X-ray edge-contrast microtomography. Scripta Mater  vol. 48, (9) 1259-1264. 10.1016/S1359-6462(03)00050-2

Mercer CE, Anderson P and Davis GR (2003). Sequential 3D X-ray microtomographic measurement of enamel and dentine ablation by an Er:YAG laser. Br Dent J  vol. 194, (2) 99-104. 10.1038/sj.bdj.4809883

ANDERSON P, Dowker SEP, Elliott JC and Bollet-Quivogne F (2003). Scanning Microradiography - a digital 2-D X-ray imaging technique. Git Imaging & Microscopy  vol. 5, 22-24.

2002

Driscoll CO, Dowker SEP, Anderson P, Wilson RM and Gulabivala K (2002). Effects of sodium hypochlorite solution on root dentine composition. J Mater Sci-Mater M  vol. 13, (2) 219-223. 10.1023/A:1013894432622

ANDERSON P, Dowker SEP, Davis GR, Elliot JC, Boyde A, Ignatiev K, Goodship A, Stock SR and Wassif HS (2002). Non-destructive 3D structural studies by X-ray microtomography. Advances in X-Ray Analysis  vol. 45, 485-490.

2001

Anderson P, Hector MP and Rampersad MA (2001). Critical pH in resting and stimulated whole saliva in groups of children and adults. Int J Paediatr Dent  vol. 11, (4) 266-273. 10.1046/j.1365-263X.2001.00293.x

Groth EB, Mercer CE and Anderson P (2001). Microtomographic analysis of subsurface enamel and dentine following Er:YAG laser and acid etching. Eur J Prosthodont Restor Dent  vol. 9, (2) 73-79.

Peariasamy K, Anderson P and Brook AH (2001). A quantitative study of the effect of pumicing and etching on the remineralisation of enamel opacities. Int J Paediatr Dent  vol. 11, (3) 193-200. 10.1046/j.1365-263X.2001.00267.x

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