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Materials Research Institute

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Dr Himadri Gupta

Himadri Gupta

Reader in Bioengineering and Biophysics

School of Engineering and Materials Science
Engineering 303A, Mile End
+44 (0)20 7882 8867

www.sems.qmul.ac.uk/h.gupta

Research

Research Interests

Our research centres on the (nanoscale) structure-function relations giving rise to the (macroscale) evolutionarily optimized mechanical properties of hierarchical biological composites like bone and arthropod cuticle. Our aims are:

(a) To understand how natural biomaterials are designed to optimally fulfil mechanical function, in order to emulate these structure in biomimetic replacements and

(b) To develop diagnostic techniques to quantify how alterations in structure in metabolic connective tissue disorders (like osteoporosis and osteoarthritis) increase fragility and fracture risk.

To achieve these aims, we develop specialized multiscale nanomechanical imaging methodologies combining high brilliance synchrotron X-ray radiation with micromechanics. This approach, pioneered in our group, enables the development of quantitative multiscale models linking nano- and microscale structure to mechanical function in biological tissues.

Publications of specific relevance to Materials Research

Publications

2021

  • Elphick M (2021). The Mutable Collagenous Tissue of Echinoderms: From Biology to Biomedical Applications. Royal Society of Chemistry  Soft Matter For Biomedical Applications  10.1039/9781839161124-00001
  • Xi L, Barbieri E, Wang P, Wu W and Gupta H (2021). Separating effects of bone-quality changes at multiple scales in steroid-induced osteoporosis: Combining multiscale experimental and modelling approaches. Mechanics of Materials  vol. 157, 10.1016/j.mechmat.2021.103821
  • Falco PD, Weinkamer R, Wagermaier W, Li C, Snow T, Terrill NJ, Gupta HS, Goyal P, Stoll M, Benner P and Fratzl P (2021). Tomographic X-ray scattering based on invariant reconstruction: Analysis of the 3D nanostructure of bovine bone. Journal of Applied Crystallography  vol. 54, 486-497. 10.1107/S1600576721000881
  • Xi L, Zhang Y, Gupta H, Terrill N, Wang P, Zhao T and Fang D (2021). A multiscale study of structural and compositional changes in a natural nanocomposite: Osteoporotic bone with chronic endogenous steroid excess. Bone  vol. 143, 10.1016/j.bone.2020.115666
  • Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M (2021). Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction., Editors: Block JA. Elsevier  Osteoarthritis and Cartilage  10.1016/j.joca.2020.08.002
  • Gupta HS, Barbieri E, Inamdar SR and Mo J (2021). Chapter 2: Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues. Rsc Soft Matter  10.1039/9781839161124-00034

2020

  • Zhang Y, Garrevoet J, Wang Y, Roeh JT, Terrill NJ, Falkenberg G, Dong Y and Gupta HS (2020). Molecular to Macroscale Energy Absorption Mechanisms in Biological Body Armour Illuminated by Scanning X-ray Diffraction with In Situ Compression. American Chemical Society  Acs Nano  10.1021/acsnano.0c02879

2019

  • Xi L, De Falco P, Barbieri E, Karunaratne A, Bentley L, Esapa CT, Davis GR, Terrill NJ, Cox RD, Pugno NM, Thakker RV, Weinkamer R, Wu WW, Fang DN and Gupta HS (2019). Reduction of fibrillar strain-rate sensitivity in steroid-induced osteoporosis linked to changes in mineralized fibrillar nanostructure. Elsevier  Bone  vol. 131, 10.1016/j.bone.2019.115111
  • Wang Y, Zhang Y, Terrill NJ, Barbieri E, Pugno NM and Gupta HS (2019). Matrix-induced pre-strain and mineralization-dependent interfibrillar shear transfer enable 3D fibrillar deformation in a biogenic armour. Elsevier  Acta Biomaterialia  10.1016/j.actbio.2019.09.036
  • Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS (2019). Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. Elsevier  Acta Biomaterialia  vol. 97, 437-450. 10.1016/j.actbio.2019.07.055

2018

  • Xi L, De Falco P, Barbieri E, Karunaratne A, Bentley L, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Davis GR, Pugno NM, Thakker RV and Gupta HS (2018). Bone matrix development in steroid-induced osteoporosis is associated with a consistently reduced fibrillar stiffness linked to altered bone mineral quality. Acta Biomaterialia  vol. 76, 295-307. 10.1016/j.actbio.2018.05.053
  • Kundanati L, Signetti S, Gupta HS, Menegon M and Pugno NM (2018). Multilayer stag beetle elytra perform better under external loading via non-symmetric bending properties. J R Soc Interface  vol. 15, (144) 10.1098/rsif.2018.0427
  • Gupta HS, Szulgit G, Elphick MR and Mo J (2018). Unlocking the secrets of mutable collagenous tissue. Biochemist  vol. 40, (1) 8-11. 10.1042/bio04001008

2017

  • Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS (2017). The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. Acs Nano  10.1021/acsnano.7b00563
  • Zhang Y, De Falco P, Wang Y, Barbieri E, Paris O, Terrill NJ, Falkenberg G, Pugno NM and Gupta HS (2017). Towards in situ determination of 3D strain and reorientation in the interpenetrating nanofibre networks of cuticle. Nanoscale  10.1039/c7nr02139a
  • Blowes LM, Egertova M, Liu Y, Davis GR, Terrill NJ, Gupta HS and ELPHICK MR (2017). Body wall structure in the starfish Asterias rubens. Wiley  Journal of Anatomy  10.1111/joa.12646
  • De Falco P, Barbieri E, Pugno N and Gupta HS (2017). Staggered Fibrils and Damageable Interfaces Lead Concurrently and Independently to Hysteretic Energy Absorption and Inhomogeneous Strain Fields in Cyclically Loaded Antler Bone. Acs Biomaterials Science & Engineering  10.1021/acsbiomaterials.6b00637
  • Gupta HS and Screen HRC (2017). Structural building blocks of soft tissues: Tendons and heart valves. Cism International Centre For Mechanical Sciences, Courses and Lectures  10.1007/978-3-319-45071-1_1

2016

  • Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ, Wang W, Elphick MR and Gupta HS (2016). Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale. Proc Natl Acad Sci U S A  10.1073/pnas.1609341113
  • Zhang Y, Paris O, Terrill NJ and Gupta HS (2016). Uncovering three-dimensional gradients in fibrillar orientation in an impact-resistant biological armour. Nature Publishing Group: Open Access Journals - Option C  Scientific Reports  vol. 6, 26249-26249. 10.1038/srep26249
  • Karunaratne A, Xi L, Bentley L, Sykes D, Boyde A, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Thakker RV and Gupta HS (2016). Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis. Bone  vol. 84, 15-24. 10.1016/j.bone.2015.11.019

2015

  • Patel IF, Kiryukhin MV, Yakovlev NL, Gupta HS and Sukhorukov GB (2015). Naturally inspired polyelectrolyte multilayer composite films synthesised through layer-by-layer assembly and chemically infiltrated with CaCO3. Journal of Materials Chemistry B  vol. 3, (24) 4821-4830. 10.1039/c5tb00055f

2014

  • Hang F, Gupta HS and BARBER AH (2014). Nanointerfacial strength between non-collagenous protein and collagen fibrils in antler bone. Royal Society Publishing  Journal of The Royal Society Interface  vol. 11, (92) 10.1098/rsif.2013.0993
  • Guerette PA, Z. Tay G, Hoon S, Loke JJ, Hermawan AF, Schmitt CNZ, Harrington MJ, Masic A, Karunaratne A, Gupta HS, Tan KS, Schwaighofer A, Nowak C and Miserez A (2014). Integrative and comparative analysis of coiled-coil based marine snail egg cases - A model for biomimetic elastomers. Biomaterials Science  vol. 2, (5) 710-722. 10.1039/c3bm60264h

2013

  • Gupta HS, Krauss S, Kerschnitzki M, Karunaratne A, Dunlop JWC, Barber AH, Boesecke P, Funari SS and Fratzl P (2013). Intrafibrillar plasticity through mineral/collagen sliding is the dominant mechanism for the extreme toughness of antler bone. Journal of The Mechanical Behavior of Biomedical Materials  vol. 28, 366-382. 10.1016/j.jmbbm.2013.03.020
  • Karunaratne A, Boyde A, Esapa CT, Hiller J, Terrill NJ, Brown SDM, Cox RD, Thakker RV and Gupta HS (2013). Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone. Bone  vol. 52, (2) 689-698. 10.1016/j.bone.2012.10.029
  • Karunaratne A, Terrill NJ and Gupta HS (2013). Synchrotron X-ray nanomechanical imaging of mineralized fiber composites. Methods Enzymol  vol. 532, 415-473. 10.1016/B978-0-12-416617-2.00019-9

2012

  • Harrington MJ, Wasko SS, Masic A, Fischer FD, Gupta HS and Fratzl P (2012). Pseudoelastic behaviour of a natural material is achieved via reversible changes in protein backbone conformation. Journal of The Royal Society Interface  vol. 9, (76) 2911-2922. 10.1098/rsif.2012.0310
  • Karunaratne A, Davis GR, Hiller J, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Thakker RV and Gupta HS (2012). Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development. Bone  vol. 51, (3) 553-562. 10.1016/j.bone.2012.04.021
  • Stachewicz U, Hang F, Bailey RJ, Gupta HS, Frogley MD, Cinque G and Barber AH (2012). Recording IR spectra for individual electrospun fibers using an in situ AFM-synchrotron technique. Materials Research Society Symposium Proceedings  vol. 1424, 19-23. 10.1557/opl.2012.151
  • Anssari-Benam A, Gupta HS and Screen HRC (2012). Strain transfer through the aortic valve. Journal of Biomechanical Engineering  vol. 134, (6) 10.1115/1.4006812
  • Karunaratne A, Esapa CR, Hiller J, Boyde A, Head R, Bassett JHD, Terrill NJ, Williams GR, Brown MA, Croucher PI, Brown SDM, Cox RD, Barber AH, Thakker RV and Gupta HS (2012). Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging. Journal of Bone and Mineral Research  vol. 27, (4) 876-890. 10.1002/jbmr.1495
  • Seto J, Busse B, Gupta HS, Schäfer C, Krauss S, Dunlop JWC, Masic A, Kerschnitzki M, Zaslansky P, Boesecke P, Catalá-Lehnen P, Schinke T, Fratzl P and Jahnen-Dechent W (2012). Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice. Plos One  vol. 7, (10) 10.1371/journal.pone.0047338

2011

  • Screen HRC, Seto J, Krauss S, Boesecke P and Gupta HS (2011). Extrafibrillar diffusion and intrafibrillar swelling at the nanoscale are associated with stress relaxation in the soft collagenous matrix tissue of tendons. Soft Matter  vol. 7, (23) 11243-11251. 10.1039/c1sm05656e
  • Wang R and Gupta HS (2011). Deformation and fracture mechanisms of bone and nacre. Annual Review of Materials Research  vol. 41, 41-73. 10.1146/annurev-matsci-062910-095806
  • Seidel R, Gourrier A, Kerschnitzki M, Burghammer M, Fratzl P, Gupta HS and Wagermaier W (2011). Synchrotron 3D SAXS analysis of bone nanostructure. Bioinspired, Biomimetic and Nanobiomaterials  vol. 1, 123-131. 10.1680/bbn.11.00014

2010

  • Gupta HS, Seto J, Krauss S, Boesecke P and Screen HRC (2010). In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen. Journal of Structural Biology  vol. 169, (2) 183-191. 10.1016/j.jsb.2009.10.002

2009

  • (2009). Rational synthesis of a nanocrystalline calcium phosphate cement exhibiting rapid conversion to hydroxyapatite. Materials Science and Engineering C  vol. 29, (7) 2124-2132. 10.1016/j.msec.2009.04.011
  • Harrington MJ, Gupta HS, Fratzl P and Waite JH (2009). Collagen insulated from tensile damage by domains that unfold reversibly: In situ X-ray investigation of mechanical yield and damage repair in the mussel byssus. Journal of Structural Biology  vol. 167, (1) 47-54. 10.1016/j.jsb.2009.03.001
  • Krauss S, Fratzl P, Seto J, Currey JD, Estevez JA, Funari SS and Gupta HS (2009). Inhomogeneous fibril stretching in antler starts after macroscopic yielding: Indication for a nanoscale toughening mechanism. Bone  vol. 44, (6) 1105-1110. 10.1016/j.bone.2009.02.009
  • Fratzl P, Gupta HS, Roschger P and Klaushofer K (2009). Nanomedicine. Nanomedicine , Editors: Vogel V, Schmid G, Krug H, Waser R and Fuchs H. Vch Pub 
  • Gupta H, Krauss S, Seto J, Wagermaier W, Kerschnitzki M, Benecke G, Zaslansky P, Boesecke P, Funari SS, Kirchner HOK and Fratzl P (2009). Nanoscale deformation mechanisms in bone. Bone  vol. 44, S33-S34. 10.1016/j.bone.2009.01.084
  • Benecke G, Kerschnitzki M, Fratzl P and Gupta HS (2009). Digital image correlation shows localized deformation bands in inelastic loading of fibrolamellar bone. Journal of Materials Research  vol. 24, (2) 421-429. 10.1557/jmr.2009.0064
  • (2009). An Effective Morphology Control of Hydroxyapatite Crystals via Hydrothermal Synthesis. Cryst Growth Des  vol. 9, (1) 466-474. 10.1021/cg800738a

2008

2007

  • Fratzl P, Gupta HS, Fischer FD and Kolednik O (2007). Hindered crack propagation in materials with periodically varying young's modulus - Lessons from biological materials. Advanced Materials  vol. 19, (18) 2657-2661. 10.1002/adma.200602394
  • Kazanci M, Wagner HD, Manjubala NI, Gupta HS, Paschalis E, Roschger P and Fratzl P (2007). Raman imaging of two orthogonal planes within cortical bone. Bone  vol. 41, (3) 456-461. 10.1016/j.bone.2007.04.200
  • Gupta HS, Fratzl P, Kerschnitzki M, Benecke G, Wagermaier W and Kirchner HOK (2007). Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV. Journal of The Royal Society Interface  vol. 4, (13) 277-282. 10.1098/rsif.2006.0172
  • Gourrier A, Wagermaier W, Burghammer M, Lammie D, Gupta HS, Fratzl P, Riekel C, Wess TJ and Paris O (2007). Scanning X-ray imaging with small-angle scattering contrast. Journal of Applied Crystallography  vol. 40, (SUPPL. 1) 10.1107/S0021889807006693
  • Wagermaier W, Gupta HS, Gourrier A, Paris O, Roschger P, Burghammer M, Riekel C and Fratzl P (2007). Scanning texture analysis of lamellar bone using microbeam synchrotron X-ray radiation. Journal of Applied Crystallography  vol. 40, (1) 115-120. 10.1107/S0021889806044888
  • Gupta HS and Fratzl P (2007). Handbook of Biomineralization: . Biological aspects and structure formation. Handbook of Biomineralization: . Biological Aspects and Structure Formation , Editors: Bäeuerlein E, Behrens P and Epple M. Vch Pub 

2006

  • Gupta HS, Seto J, Wagermaier W, Zaslansky P, Boesecke P and Fratzl P (2006). Cooperative deformation of mineral and collagen in bone at the nanoscale. Proc Natl Acad Sci U S A  vol. 103, (47) 17741-17746. 10.1073/pnas.0604237103
  • Gupta HS, Stachewicz U, Wagermaier W, Roschger P, Wagner HD and Fratzl P (2006). Mechanical modulation at the lamellar level in osteonal bone. Journal of Materials Research  vol. 21, (8) 1913-1921. 10.1557/jmr.2006.0234
  • Gupta HS, Wagermaier W, Zickler GA, Hartmann J, Funari SS, Roschger P, Wagner DH and Fratzl P (2006). Fibrillar level fracture in bone beyond the yield point. International Journal of Fracture  vol. 139, (3-4) 425-436. 10.1007/s10704-006-6635-y
  • Wagermaier W, Gupta HS, Gourrier A, Burghammer M, Roschger P and Fratzl P (2006). Spiral twisting of fiber orientation inside bone lamellae. Biointerphases  vol. 1, (1) 1-5. 10.1116/1.2178386

2005

  • Gehrke N, Nassif N, Pinna N, Antonietti M, Gupta HS and Cölfen H (2005). Retrosynthesis of nacre via amorphous precursor particles. Chemistry of Materials  vol. 17, (26) 6514-6516. 10.1021/cm052150k
  • Gupta HS, Wagermaier W, Zickler GA, Aroush DRB, Funari SS, Roschger P, Wagner HD and Fratzl P (2005). Nanoscale deformation mechanisms in bone. Nano Letters  vol. 5, (10) 2108-2111. 10.1021/nl051584b
  • Fratzl P, Gupta HS, Paris O, Valenta A, Roschger P and Klaushofer K (2005). Diffracting stacks of cards - Some thoughts about small-angle scattering from bone. Progress in Colloid and Polymer Science  vol. 130, 33-39. 10.1007/b107343
  • Gupta HS, Schratter S, Tesch W, Roschger P, Berzlanovich A, Schoeberl T, Klaushofer K and Fratzl P (2005). Two different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface. Journal of Structural Biology  vol. 149, (2) 138-148. 10.1016/j.jsb.2004.10.010

2004

  • Fratzl P, Burgert I and Gupta HS (2004). On the role of interface polymers for the mechanics of natural polymeric composites. Physical Chemistry Chemical Physics  vol. 6, (24) 5575-5579. 10.1039/b411986j
  • Gindl W, Gupta HS, Schöberl T, Lichtenegger HC and Fratzl P (2004). Mechanical properties of spruce wood cell walls by nanoindentation. Applied Physics a: Materials Science and Processing  vol. 79, (8) 2069-2073. 10.1007/s00339-004-2864-y
  • Gupta HS, Messmer P, Roschger P, Bernstorff S, Klaushofer K and Fratzl P (2004). Synchrotron diffraction study of deformation mechanisms in mineralized tendon. Physical Review Letters  vol. 93, (15) 10.1103/PhysRevLett.93.158101
  • Fratzl P, Gupta HS, Paschalis EP and Roschger P (2004). Structure and mechanical quality of the collagen-mineral nano-composite in bone. Journal of Materials Chemistry  vol. 14, (14) 2115-2123. 10.1039/b402005g
  • Weinkamer R, Fratzl P, Gupta HS, Penrose O and Lebowitz JL (2004). Using kinetic Monte Carlo simulations to study phase separation in alloys. Phase Transitions  vol. 77, (5-7) 433-456. 10.1080/01411590410001672639

2003

  • Schöberl T, Gupta HS and Fratzl P (2003). Measurements of mechanical properties in Ni-base superalloys using nanoindentation and atomic force microscopy. Materials Science and Engineering A  vol. 363, (1-2) 211-220. 10.1016/S0921-5093(03)00627-0
  • Gupta HS, Roschger P, Zizak I, Fratzl-Zelman N, Nader A, Klaushofer K and Fratzl P (2003). Mineralized microstructure of calcified avian tendons: A scanning small angle X-ray scattering study. Calcified Tissue International  vol. 72, (5) 567-576. 10.1007/s00223-002-1031-8
  • Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P, Cosman F, Parisien M, Lindsay R, Nieves JW and Klaushofer K (2003). Constant mineralization density distribution in cancellous human bone. Bone  vol. 32, (3) 316-323. 10.1016/S8756-3282(02)00973-0
  • Schöberl T and Gupta HS (2003). Effect of interphase boundaries on nanoindentation experiments on a Ni-base alloy. Zeitschrift Fuer Metallkunde/Materials Research and Advanced Techniques  vol. 94, (7) 813-818. 10.3139/146.030813

2002

  • Gindl W, Gupta HS and Grunwald C (2002). Lignification of spruce tracheid secondary cell walls related to longitudinal hardness and modulus of elasticity using nano-indentation. Can J Bot  vol. 80, (10) 1029-1033. 10.1139/B02-091
  • Gindl W and Gupta HS (2002). Cell-wall hardness and Young's modulus of melamine-modified spruce wood by nano-indentation. Composites Part a: Applied Science and Manufacturing  vol. 33, (8) 1141-1145. 10.1016/S1359-835X(02)00080-5

2001

  • Weinkamer R, Gupta H, Lebowitz JL and Fratzl P (2001). Precipitate size distribution in alloys with and without lattice misfit. Zeitschrift Fuer Metallkunde/Materials Research and Advanced Techniques  vol. 92, (1) 9-13.
  • Gupta H, Weinkamer R, Fratzl P and Lebowitz JL (2001). Microscopic computer simulations of directional coarsening in face-centered cubic alloys. Elsevier  Acta Materialia  vol. 49, (1) 53-63. 10.1016/S1359-6454(00)00303-7

2000

  • Weinkamer R, Gupta H, Fratzl P and Lebowitz JL (2000). Dynamics of mesoscopic precipitate lattices in phase-separating alloys under external load. Europhysics Letters  vol. 52, (2) 224-230. 10.1209/epl/i2000-00427-7

1996

Grants of specific relevance to Materials Research

Grants

  • Nanoscale damage markers for early osteoarthritis detection in the bone-cartilage unit
    Gupta HS
    £70,000 Engineering and Physical Sciences Research Council (01-09-2019 - 31-05-2023)
    Abstract
  • Imaging dynamics in biophysical/biochemical processes across the hierarchical scales (BioPro Network)
    Gupta H
    £609,196 Medical Research Council (01-05-2018 - 01-04-2022)
    Abstract


  • The mechanics of the collagen fibrillar network in ageing cartilage
    Gupta HS and Knight MM
    £369,874 Biotechnology and Biological Sciences Research Council (30-09-2017 - 29-09-2020)
    Abstract
  • Neuropeptide function in a decentralised nervous system
    Elphick MR and Gupta HS
    £354,356 Biotechnology and Biological Sciences Research Council (02-02-2015 - 31-08-2018)
    Abstract