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Dr Karin Hing

Karin HingCEng, PhD, BSc, MIMMM, FRMS

Reader in Biomedical Materials

School of Engineering and Materials Science
Engineering 116, Mile End
+44 (0)20 7882 7804

www.sems.qmul.ac.uk/k.a.hing

Research

Research Interests

Karin’s main research interests center on development of novel biomaterials and treatment therapies to promote bone healing through investigation of the mechanisms behind the sensitivity of bone regeneration to the materials characteristics of  synthetic bone graft substitute materials. This has led to pioneering work on development of osteoinductive grafts with biomimetic hierarchical porous structures and study of the physio-chemical phenomena that control protein adsorption and ion exchange at the graft-bone interface to stimulate bone cell bioactivity. Subjects that reflect her interests in the effect these phenomena have on both the anabolic and catabolic sides of bone metabolism. Additionally she is also active in the study of regeneration in associated non-calcified musculo-skeletal tissues.

Publications of specific relevance to Materials Research

Publications

2021

  • Zhou B, Das A, Zhong M, Guo Q, Zhang DW, Hing KA, Sobrido AJ, Titirici MM and Krause S (2021). Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responses. Biosensors and Bioelectronics  vol. 180, 10.1016/j.bios.2021.113121

2020

  • Hexter AT, Hing KA, Haddad FS and Blunn G (2020). Decellularized porcine xenograft for anterior cruciate ligament reconstruction: A histological study in sheep comparing cross-pin and cortical suspensory femoral fixation. The British Editorial Society of Bone & Joint Surgery  Bone and Joint Research  vol. 9, (6) 293-301. 10.1302/2046-3758.96.BJR-2020-0030.R2

2019

2017

  • Mafina MK, Sullivan AC and Hing KA (2017). Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditions. Materials Science and Engineering C  vol. 80, 207-212. 10.1016/j.msec.2017.05.142
  • Sriranganathan D, Chen X, Hing KA, Kanwal N and Hill RG (2017). The effect of the incorporation of fluoride into strontium containing bioactive glasses. Journal of Non-Crystalline Solids  vol. 457, 25-30. 10.1016/j.jnoncrysol.2016.11.018

2016

  • Campion C and Hing KA (2016). Porous Bone Graft Substitutes: When Less is More. Mechanobiology: Exploitation For Medical Benefit  10.1002/9781118966174.ch21
  • Sriranganathan D, Kanwal N, Hing KA and Hill RG (2016). Strontium substituted bioactive glasses for tissue engineered scaffolds: the importance of octacalcium phosphate. Journal of Materials Science: Materials in Medicine  vol. 27, (2) 1-10. 10.1007/s10856-015-5653-6
  • Coathup MJ, Blunn GW, Campion C, Ho C-Y and Hing KA (2016). The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model. J Biomed Mater Res B Appl Biomater  vol. 105, (4) 805-814. 10.1002/jbm.b.33614

2015

  • Hutchens SA, Campion C, Assad M, Chagnon M and Hing KA (2015). Efficacy of silicate-substituted calcium phosphate with enhanced strut porosity as a standalone bone graft substitute and autograft extender in an ovine distal femoral critical defect model. J Mater Sci Mater Med  vol. 27, (1) 20-20. 10.1007/s10856-015-5559-3
  • Shah FA, Brauer DS, Hill RG and Hing KA (2015). Apatite formation of bioactive glasses is enhanced by low additions of fluoride but delayed in the presence of serum proteins. Materials Letters  vol. 153, 143-147. 10.1016/j.matlet.2015.04.013

2014

  • Shah FA, Brauer DS, Desai N, Hill RG and Hing KA (2014). Fluoride-containing bioactive glasses and Bioglass® 45S5 form apatite in low pH cell culture medium. Materials Letters  vol. 119, 96-99. 10.1016/j.matlet.2013.12.102
  • Shah FA, Brauer DS, Wilson RM, Hill RG and Hing KA (2014). Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride-containing bioactive glass. Journal of Biomedical Materials Research - Part A  vol. 102, (3) 647-654. 10.1002/jbm.a.34724

2013

  • Castagna V, Olivares-Navarrete R, Schwartz Z, Boyan BD and Hing KA (2013). HMSC proliferation and differentiation are dependent on chemistry and surface roughness of calcium phosphate bone substitutes. European Cells and Materials  vol. 26, (SUPPL. 3)
  • Campion CR, Ball SL, Clarke DL and Hing KA (2013). Microstructure and chemistry affects apatite nucleation on calcium phosphate bone graft substitutes. Journal of Materials Science: Materials in Medicine  vol. 24, (3) 597-610. 10.1007/s10856-012-4833-x
  • Mafina M-K, Hing KA and Sullivan AC (2013). Development of novel fluorescent probes for the analysis of protein interactions under physiological conditions with medical devices. Langmuir  vol. 29, (5) 1420-1426. 10.1021/la304244s
  • Ghani Y, Coathup MJ, Hing KA and Blunn GW (2013). Antibacterial effect of incorporating silver ions in electrochemically deposited hydroxyapatite coating: An experimental study. Jrsm Short Rep  vol. 4, (9) 10.1177/2042533313481212
  • Hing KA (2013). Biomimetic bone regeneration. 10.1533/9780857098887.2.207
  • Hing KA (2013). 8 Biomimetic bone regeneration. Biomimetic Biomaterials  10.1533/9780857098887.2.207
  • Ruys A, Tampieri A, Sprio S, Ehrlich H, Rabiei R, Dastjerdi AK, Mirkhalaf M, Barthelat F, Chánová EM, Rypá¿ek F, Boughton P, Roger G, Rohanizadeh R, Mason RS, Boughton E, McLennan SV, Le Bao Ha T, Hing KA, Zhu J, Hu J, Marchant RE and Campbell D (2013). Contributor contact details. Biomimetic Biomaterials  10.1016/b978-0-85709-416-2.50013-6

2012

  • Chan O, Coathup MJ, Nesbitt A, Ho CY, Hing KA, Buckland T, Campion C and Blunn GW (2012). The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterials. Acta Biomaterialia  vol. 8, (7) 2788-2794. 10.1016/j.actbio.2012.03.038
  • Coathup MJ, Hing KA, Samizadeh S, Chan O, Fang YS, Campion C, Buckland T and Blunn GW (2012). Effect of increased strut porosity of calcium phosphate bone graft substitute biomaterials on osteoinduction. Journal of Biomedical Materials Research - Part A  vol. 100 A, (6) 1550-1555. 10.1002/jbm.a.34094
  • Ghani Y, Coathup MJ, Hing KA and Blunn GW (2012). Development of a hydroxyapatite coating containing silver for the prevention of peri-prosthetic infection. J Orthop Res  vol. 30, (3) 356-363. 10.1002/jor.21543
  • Ozad U, Parish A and Hing KA (2012). Bioactivity And Bone Formation In Silicon-Substituted Hydroxyapatite. Sakarya University Journal of Science  vol. 16, (3) 170-177. 10.5505/saufbe.2012.42104

2011

  • Coathup MJ, Samizadeh S, Fang YS, Buckland T, Hing KA and Blunn GW (2011). The osteoinductivity of silicate-substituted calcium phosphate. J Bone Joint Surg Am  vol. 93, (23) 2219-2226. 10.2106/JBJS.I.01623
  • Parish A, Davis G and Hing K (2011). The quantitative and qualitative analysis bone ingrowth network quality of hydroxyapatite implants over time to investigate the process of internal bone growth via novel automated 3D image processing. 24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials 
  • Castagna V, Sullivan A and Hing K (2011). Fibronectin adsorption to stoichiometric and silicate substituted hydroxyapatite sensitive to FN concentration and presence of serum proteins. 24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials 
  • Guth K, Campion C, Buckland T and Hing KA (2011). Effects of serum protein on ionic exchange between culture medium and microporous hydroxyapatite and silicate-substituted hydroxyapatite. Journal of Materials Science: Materials in Medicine  vol. 22, (10) 2155-2164. 10.1007/s10856-011-4409-1
  • Campion CR, Chander C, Buckland T and Hing K (2011). Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesis. Journal of Biomedical Materials Research - Part B Applied Biomaterials  vol. 97 B, (2) 245-254. 10.1002/jbm.b.31807
  • Castagna V, Sullivan A and Hing KA (2011). Behaviour of fibronectin on interaction with stoichiometric and silicate substituted hydroxyapatite bone graft substitiutes. European Cells and Materials  vol. 22, (SUPPL.2)
  • Mafina MK, Sullivan AC and Hing KA (2011). Recording and evaluating the effect of silicon-substitution on protein adsorption/desorption to hydroxyapatite. European Cells and Materials  vol. 22, (SUPPL.2)
  • Parish AJB, Davis GR and Hing KA (2011). Automated computation of 3D histomorphometry within implanted hydroxyapatite porous scaffolds. European Cells and Materials  vol. 22, (SUPPL.2)

2010

  • Hing K (2010). Tissue engineering. Mater World  vol. 18, (9) 28-30.
  • Guth K, Campion C, Buckland T and Hing KA (2010). Surface physiochemistry affects protein adsorption to stoichiometric and silicate-substituted microporous hydroxyapatites. Advanced Engineering Materials  vol. 12, (4) 10.1002/adem.200980026
  • Guth K, Campion C, Buckland T and Hing KA (2010). Effect of silicate-substitution on attachment and early development of human osteoblast-like cells seeded on microporous hydroxyapatite discs. Advanced Engineering Materials  vol. 12, (1-2) 10.1002/adem.200980003

2009

  • Mafina MK, Sullivan AC and Hing KA (2009). Monitoring the effect of silicate substitution on protein adsorption/desorption to hydroxyapatite. European Cells and Materials  vol. 18, (SUPPL. 2)

2008

  • Samizadeh S, Amogbokpa J, Fang SC, Coathup MJ, Hing KA, Buckland T and Blunn GW (2008). Osseoinduction by calcium phosphate bone substitutes is a function of chemical composition and structure. 8th World Biomaterials Congress 2008  vol. 2,
  • Hing KA (2008). Biomaterials - Where biology, physics, chemistry, engineering and medicine meet. Journal of Physics: Conference Series  vol. 105, (1) 10.1088/1742-6596/105/1/012010
  • Rashid N, Harding I, Buckland T and HING KA (2008). Nano-scale manipulation of silicate-substituted apatite chemistry impacts surface charge, hydrophilicity, protein adsorption and cell attachment., Editors: Meenan BJ and Boyd AR. International Journal of Nano and Biomaterials  vol. 1, (3) 299-319. 10.1504/IJNBM.2008.016877

2007

2006

  • Hing KA, Revell PA, Smith N and Buckland T (2006). Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds. Biomaterials  vol. 27, (29) 5014-5026. 10.1016/j.biomaterials.2006.05.039
  • De Carlos A, Lusquinos F, Pou J, Leon B, Perez-Amor M, Driessens FCM, HING KA, Best S and Bonfield W (2006). In vitro testing of Nd : YAG laser processed calcium phosphate coatings. Journal of Materials Science Materials in Medicine  vol. 17, (11) 1153-1160.

2005

  • Harding IS, Rashid N and Hing KA (2005). Surface charge and the effect of excess calcium ions on the hydroxyapatite surface. Biomaterials  vol. 26, (34) 6818-6826. 10.1016/j.biomaterials.2005.04.060
  • Mehta JS, Futter CE, Sandeman SR, Faragher RGAF, Hing KA, Tanner KE and Allan BDS (2005). Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materials. Br J Ophthalmol  vol. 89, (10) 1356-1362. 10.1136/bjo.2004.064147
  • HING KA, Annaz B, Saeed S, Revell PA and Buckland T (2005). Microporosity enhances bioactivity of synthetic bone graft substitutes. Journal of Materials Science Materials in Medicine  vol. 16, (5) 467-475.
  • Hing KA (2005). Bioceramic bone graft substitutes: Influence of porosity and chemistry. Int J Appl Ceram Tec  vol. 2, (3) 184-199. 10.1111/j.1744-7402.2005.02020.x

2004

  • Hing KA (2004). Bone repair in the twenty-first century: biology, chemistry or engineering? Philos Trans a Math Phys Eng Sci  vol. 362, (1825) 2821-2850. 10.1098/rsta.2004.1466
  • Rashid N, Harding I and Hing KA (2004). Effect of silicate substitution on the surface charge of hydroxyapatite. Transactions - 7th World Biomaterials Congress 
  • Hing KA, Saeed S, Annaz B, Buckland T and Revell PA (2004). Bone development is sensitive to silicon level in substituted apatites. Transactions - 7th World Biomaterials Congress 
  • Hing KA, Saeed S, Annaz B, Buckland T and Revell PA (2004). Microporosity enhances bioactivity of synthetic bone graft substitutes. Transactions - 7th World Biomaterials Congress 
  • Saeed S, Hing K and Revell PA (2004). HA activates T cells and causes inflammation in liver and spleen from rabbits following intraosseous implantation. Transactions - 7th World Biomaterials Congress 
  • Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L (2004). The role of microporosity in synthetic porous ceramics. Transactions - 7th World Biomaterials Congress 
  • Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L (2004). An ultrastructural study of cellular response to variation in porosity in phase-pure hydroxyapatite. J Microsc  vol. 216, (Pt 2) 97-109. 10.1111/j.0022-2720.2004.01403.x
  • Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L (2004). Porosity variation in hydroxyapatite and osteoblast morphology: a scanning electron microscopy study. J Microsc  vol. 215, (Pt 1) 100-110. 10.1111/j.0022-2720.2004.01354.x
  • HING KA, Tanner KE, Best SM, Bonfield W and Revell PA (2004). Mediation of bone ingrowth in porous hydroxyaptite bone graft substitutes. Journal of Biomedical Materials Research  vol. 68A, 187-200. 10.1002/jbm.a.10050
  • HING KA, Revell PA, McInness T and Damien E (2004). Novel Bioceramic Foams For Bone Grafting. Journal of Bone & Joint Surgery - British Volume  vol. 86-B Suppl I:II,
  • Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA (2004). Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes. J Biomed Mater Res A  vol. 68, (1) 187-200. 10.1002/jbm.a.10050

2003

  • Damien E, Hing K, Saeed S and Revell PA (2003). A preliminary study on the enhancement of the osteointegration of a novel synthetic hydroxyapatite scaffold in vivo. J Biomed Mater Res A  vol. 66, (2) 241-246. 10.1002/jbm.a.10564
  • Lusquiños F, De Carlos A, Pou J, Arias JL, Boutinguiza M, León B, Pérez-Amor M, Driessens FCM, Hing K, Gibson I, Best S and Bonfield W (2003). Calcium phosphate coatings obtained by Nd:YAG laser cladding: physicochemical and biologic properties. J Biomed Mater Res A  vol. 64, (4) 630-637. 10.1002/jbm.a.10440

2002

  • Patel N, Best SM, Bonfield W, Gibson IR, Hing KA, Damien E and Revell PA (2002). A comparative study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules. J Mater Sci Mater Med  vol. 13, (12) 1199-1206. 10.1023/a:1021114710076

2001

  • Damien E, MacInnes T, Hing K and Revell PA (2001). Insulin like growth factor (IGF-I) increases the bioactivity of porous hydroxyapatite (PHA) in vivo in rabbits. J Pathol  vol. 193, 6A-6A.

1999

  • Hing KA, Best SM and Bonfield W (1999). Characterization of porous hydroxyapatite. J Mater Sci Mater Med  vol. 10, (3) 135-145. 10.1023/a:1008929305897
  • Di Silvio L, Hing K and Bonfield W (1999). Macroporous hydroxyapatites: Potential drug delivery systems. Proceedings of The Controlled Release Society  (26) 1152-1153.
  • Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA (1999). Quantification of bone ingrowth within bone-derived porous hydroxyapatite implants of varying density. Journal of Materials Science: Materials in Medicine  vol. 10, (10-11) 663-670. 10.1023/a:1008900127475

1998

  • Hing K and Knight M (1998). Prize-winning peeks at the microscopic world.
  • Hing KA, Best SM, Tanner KE, Réveil PA and Bonfield W (1998). Histomorphological and biomechanical characterization of calcium phosphates in the osseous environment. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine  vol. 212, (6) 437-451. 10.1243/0954411981534204

1997

  • Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA (1997). Biomechanical assessment of bone ingrowth in porous hydroxyapatite. Journal of Materials Science: Materials in Medicine  vol. 8, (12) 731-736. 10.1023/A:1018500309969

1996

  • Hing KA, Best SM, Revell PA, Tanner KE and Bonfield W (1996). Histomorphometric and biomechanical assessment of bone ingrowth in porous hydroxyapatite. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium  vol. 2,
  • HING KA (1996). Assessment of porous hydroxyapatite for bone replacement., Editors: Best SM and Bonfield W.

Grants of specific relevance to Materials Research

Grants

  • Lucideon-QMUL Cell testing to assist development of novel biomaterials
    Hing K, Rawlinson S and Shepherd D
    £249,854 Innovate UK (15-03-2021 - 14-09-2023)
    Abstract