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Materials Research Institute

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Dr Maxie Roessler

Lecturer in Chemistry and Biochemistry

Department School of Biological and Chemical Sciences
 Room 1.03, Joseph Priestley Building
Telephone +44 (0)20 7882 6627
Email m.roessler@qmul.ac.uk
Homepage http://www.sbcs.qmul.ac.uk/staff/maxieroessler.html

Research Interests

TBC

Key Publications

Evans RM, Parkin A, Roessler MM, Murphy BJ, Adamson H, Lukey MJ, Sargent F, Volbeda A, Fontecilla-Camps JC and Armstrong FA (2013). Principles of Sustained Enzymatic Hydrogen Oxidation in the Presence of Oxygen ? The Crucial Influence of High Potential Fe?S Clusters in the Electron Relay of [NiFe]-Hydrogenases. American Chemical Society  Journal of The American Chemical Society  vol. 135, (7) 2694-2707. 10.1021/ja311055d

Roessler MM, Evans RM, Davies RA, Harmer J and Armstrong FA (2012). EPR spectroscopic studies of the Fe-S clusters in the O2-tolerant [NiFe]-hydrogenase Hyd-1 from Escherichia coli and characterization of the unique [4Fe-3S] cluster by HYSCORE. J Am Chem Soc  vol. 134, (37) 15581-15594. 10.1021/ja307117y

Lukey MJ, Roessler MM, Parkin A, Evans RM, Davies RA, Lenz O, Friedrich B, Sargent F and Armstrong FA (2011). Oxygen-tolerant [NiFe]-hydrogenases: the individual and collective importance of supernumerary cysteines at the proximal Fe-S cluster. J Am Chem Soc  vol. 133, (42) 16881-16892. 10.1021/ja205393w

Roessler MM, King MS, Robinson AJ, Armstrong FA, Harmer J and Hirst J (2010). Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance. Proc Natl Acad Sci U S A  vol. 107, (5) 1930-1935. 10.1073/pnas.0908050107

2018

Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S and Isaacson RL (2018). Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control. Bmc Biol  vol. 16, (1) 10.1186/s12915-018-0542-3

ROESSLER MM and SALVADORI E (2018). Principles and applications of EPR spectroscopy in the chemical sciences. Royal Society of Chemistry  Chemical Society Reviews  10.1039/C6CS00565A

2017

Le Breton N, Wright JJ, Jones AJY, Salvadori E, Bridges HR, Hirst J and Roessler MM (2017). Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I. J Am Chem Soc  vol. 139, (45) 16319-16326. 10.1021/jacs.7b09261

Adamson H, Robinson M, Wright JJ, Flanagan LA, Walton J, Elton D, Gavaghan DJ, Bond AM, Roessler MM and Parkin A (2017). Retuning the Catalytic Bias and Overpotential of a [NiFe]-Hydrogenase via a Single Amino Acid Exchange at the Electron Entry/Exit Site. J Am Chem Soc  vol. 139, (31) 10677-10686. 10.1021/jacs.7b03611

2016

Flanagan LA, Wright JJ, Roessler MM, Moir JW and Parkin A (2016). Re-engineering a NiFe hydrogenase to increase the H2 production bias while maintaining native levels of O2 tolerance. Chem Commun (Camb)  vol. 52, (58) 9133-9136. 10.1039/c6cc00515b

Hirst J and Roessler MM (2016). Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I. Biochimica Et Biophysica Acta - Bioenergetics  vol. 1857, (7) 872-883. 10.1016/j.bbabio.2015.12.009

2015

Murphy BJ, Hidalgo R, Roessler MM, Evans RM, Ash PA, Myers WK, Vincent KA and Armstrong FA (2015). Discovery of Dark pH-Dependent H(+) Migration in a [NiFe]-Hydrogenase and Its Mechanistic Relevance: Mobilizing the Hydrido Ligand of the Ni-C Intermediate. J Am Chem Soc  vol. 137, (26) 8484-8489. 10.1021/jacs.5b03182

2013

Evans RM, Parkin A, Roessler MM, Murphy BJ, Adamson H, Lukey MJ, Sargent F, Volbeda A, Fontecilla-Camps JC and Armstrong FA (2013). Principles of Sustained Enzymatic Hydrogen Oxidation in the Presence of Oxygen ? The Crucial Influence of High Potential Fe?S Clusters in the Electron Relay of [NiFe]-Hydrogenases. American Chemical Society  Journal of The American Chemical Society  vol. 135, (7) 2694-2707. 10.1021/ja311055d

2012

Roessler MM, Evans RM, Davies RA, Harmer J and Armstrong FA (2012). EPR spectroscopic studies of the Fe-S clusters in the O2-tolerant [NiFe]-hydrogenase Hyd-1 from Escherichia coli and characterization of the unique [4Fe-3S] cluster by HYSCORE. J Am Chem Soc  vol. 134, (37) 15581-15594. 10.1021/ja307117y

Volbeda A, Amara P, Darnault C, Mouesca J, Parkin A, Roessler MM, Armstrong FA and Fontecilla-Camps JC (2012). X-ray crystallographic and computational studies of the O2-tolerant [NiFe]-hydrogenase 1 from Escherichia coli., Editors: Holm R. Proceedings of The National Academy of Sciences (Pnas)  Proceedings of The National Academy of Sciences  vol. 109, (14) 5305-5310. 10.1073/pnas.1119806109

Parkin A, Bowman L, Roessler MM, Davies RA, Palmer T, Armstrong FA and Sargent F (2012). How Salmonella oxidises H2 under aerobic conditions. Elsevier/Science Direct  Febs Letters  vol. 586, (5) 536-544. 10.1016/j.febslet.2011.07.044

2011

Lukey MJ, Roessler MM, Parkin A, Evans RM, Davies RA, Lenz O, Friedrich B, Sargent F and Armstrong FA (2011). Oxygen-tolerant [NiFe]-hydrogenases: the individual and collective importance of supernumerary cysteines at the proximal Fe-S cluster. J Am Chem Soc  vol. 133, (42) 16881-16892. 10.1021/ja205393w

Lee C, Stevenson GP, Parkin A, Roessler MM, Baker RE, Gillow K, Gavaghan DJ, Armstrong FA and Bond AM (2011). Theoretical and experimental investigation of surface-confined two-center metalloproteins by large-amplitude Fourier transformed ac voltammetry. Journal of Electroanalytical Chemistry  vol. 656, (1?2) 293-303. 10.1016/j.jelechem.2010.08.012

2010

Lukey MJ, Parkin A, Roessler MM, Murphy BJ, Harmer J, Palmer T, Sargent F and Armstrong FA (2010). How Escherichia coli Is Equipped to Oxidize Hydrogen under Different Redox Conditions. Journal of Biological Chemistry  vol. 285, (6) 3928-3938. 10.1074/jbc.M109.067751

Roessler MM, King MS, Robinson AJ, Armstrong FA, Harmer J and Hirst J (2010). Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance. Proc Natl Acad Sci U S A  vol. 107, (5) 1930-1935. 10.1073/pnas.0908050107

TBC

TBC

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