Dr Natalia Karpukhina

Senior Lecturer
Institute of Dentistry
Dental Physical Sciences Unit, 2nd Fl. Francis Bancroft Building, Mile End
+44 (0)20 7882 5975
n.karpukhina@qmul.ac.uk
https://www.materials.qmul.ac.uk/people/?n.karpukhina
Research Interests
I am working in area of biomedical materials. I use solid-state nuclear magnetic resonance (NMR) spectroscopy to investigate structure of various glasses, cements and apatites. Solid-state NMR is extremely powerful technique to study structure of solids in particular, amorphous solids, and equally informative for crystalline solids. We study structure of bioactive silicate and phosphate glasses containing halogen and other components. We also investigate the setting reactions in various dental and bone cements including glass ionomer cements, calcium, magnesium and zinc phosphate cements using solid-state NMR. We study structure and properties of dental glass ceramics and various substitutions in apatites. Using solid-state NMR in combination with other techniques we also study structure of teeth, bones and other natural apatites. We apply our knowledge on structure of various biomaterials for designing materials for specific biomedical applications. I supervise PhD students and MSc research projects.
Key Publications
KARPUKHINA N, Gao Y and Law RV (2016). Phase Segregation in Hydroxyfluorapatite Solid Solution at High Temperatures Studied by Combined XRD/Solid State NMR. Royal Society of Chemistry Rsc Advances (105) 103782-103790. 10.1039/C6RA17161C
Zainuddin N, Karpukhina N, Law RV and Hill RG (2012). Characterisation of a remineralising Glass Carbomer (R) ionomer cement by MAS-NMR Spectroscopy. Dental Materials vol. 28, (10) 1051-1058. 10.1016/j.dental.2012.06.011
Fredholm YC, Karpukhina N, Brauer DS, Jones JR, Law RV and Hill RG (2012). Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation. Journal of The Royal Society Interface vol. 9, (70) 880-889. 10.1098/rsif.2011.0387
Fujikura K, Karpukhina N, Kasuga T, Brauer DS, Hill RG and Law RV (2012). Influence of strontium substitution on structure and crystallisation of Bioglass (R) 45S5. Journal of Materials Chemistry vol. 22, (15) 7395-7402. 10.1039/c2jm14674f
Brauer DS, Karpukhina N, O'Donnell MD, Law RV and Hill RG (2010). Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. Acta Biomater vol. 6, (8) 3275-3282. 10.1016/j.actbio.2010.01.043
2018
Duminis T, Shahid S, Karpukhina NG and Hill RG (2018). Predicting refractive index of fluoride containing glasses for aesthetic dental restorations. Dent Mater vol. 34, (5) e83-e88. 10.1016/j.dental.2018.01.024
Pedone A, Chen X, Hill RG and Karpukhina N (2018). Molecular Dynamics Investigation of Halide-Containing Phospho-Silicate Bioactive Glasses. J Phys Chem B vol. 122, (11) 2940-2948. 10.1021/acs.jpcb.8b00547
Kanwal N, Brauer DS, Earl J, Wilson RM, Karpukhina N and Hill RG (2018). In-vitro apatite formation capacity of a bioactive glass - containing toothpaste. J Dent vol. 68, 51-58. 10.1016/j.jdent.2017.10.015
Simila HO, Karpukhina N and Hill RG (2018). Bioactivity and fluoride release of strontium and fluoride modified Biodentine. Dent Mater vol. 34, (1) e1-e7. 10.1016/j.dental.2017.10.005
Kent NW, Blunn G, Karpukhina N, Davis G, de Godoy RF, Wilson RM, Coathup M, Onwordi L, Quak WY and Hill R (2018). In vitro and in vivo study of commercial calcium phosphate cement HydroSet?. J Biomed Mater Res B Appl Biomater vol. 106, (1) 21-30. 10.1002/jbm.b.33809
2017
KARPUKHINA N, Chen X, Chen X, Brauer DS, Wilson RM, Law RV and Hill RG (2017). Sodium is not essential for high bioactivity of glasses. Wiley International Journal of Applied Glass Science 10.1111/ijag.12323
Swansbury LA, Mountjoy G, Chen X, Karpukhina N and Hill R (2017). Modeling the Onset of Phase Separation in CaO-SiO2-CaCl2 Chlorine-Containing Silicate Glasses. J Phys Chem B vol. 121, (22) 5647-5653. 10.1021/acs.jpcb.7b02986
Chen X, Karpukhina N, Brauer DS and Hill RG (2017). High chloride content calcium silicate glasses. Phys Chem Chem Phys vol. 19, (10) 7078-7085. 10.1039/c6cp07905a
2016
KARPUKHINA N, Gao Y and Law RV (2016). Phase Segregation in Hydroxyfluorapatite Solid Solution at High Temperatures Studied by Combined XRD/Solid State NMR. Royal Society of Chemistry Rsc Advances (105) 103782-103790. 10.1039/C6RA17161C
Kusumoto H, Abolghasemi S, Woodfine B, Hill RG, Karpukhina N and Law RV (2016). The effect of phosphate, fluorine, and soda content of the glass on the mechanical properties of the glass ionomer (polyalkenoate) cements. Journal of Non-Crystalline Solids vol. 449, 94-99. 10.1016/j.jnoncrysol.2016.06.036
Kent NW, Hill RG and Karpukhina N (2016). A new way of forming a calcium phosphate cement using bioactive glasses as a reactive precursor. Materials Letters vol. 162, 32-36. 10.1016/j.matlet.2015.09.099
2015
Al Mansour F, Karpukhina N, Grasso S, Wilson RM, Reece MJ and Cattell MJ (2015). The effect of spark plasma sintering on lithium disilicate glass-ceramics. Dent Mater vol. 31, (10) e226-e235. 10.1016/j.dental.2015.07.001
Bingel L, Groh D, Karpukhina N and Brauer DS (2015). Influence of dissolution medium pH on ion release and apatite formation of Bioglass? 45S5. Materials Letters vol. 143, 279-282. 10.1016/j.matlet.2014.12.124
Chen X, Karpukhina N, Brauer DS and Hill RG (2015). Novel highly degradable chloride containing bioactive glasses. Biomedical Glasses vol. 1, (1) 108-118. 10.1515/bglass-2015-0010
Kanwal N, Toms H, Hannon AC, Perras FA, Bryce DL, Karpukhina N and Abrahams I (2015). Structure and solubility behaviour of zinc containing phosphate glasses. Journal of Materials Chemistry B vol. 3, (45) 8842-8855. 10.1039/c4tb01504e
Tang HM, Shahid S, Karpukhina N, Law RV and Hill RG (2015). Glass polyalkenoate cements based on simple CaO-Al
2014
CATTELL MJ, Karpukhina N and Almuhamadi J (2014). Diopside Glass-Ceramics for Dental and Biomedical Applications. Advances in Science and Technology. vol. 96, 10.4028/www.scientific.net/AST.96.15
Chen X, Chen X, Brauer DS, Wilson RM, Hill RG and Karpukhina N (2014). Novel alkali free bioactive fluorapatite glass ceramics. Journal of Non-Crystalline Solids vol. 402, 172-177. 10.1016/j.jnoncrysol.2014.05.025
Chen X, Brauer DS, Karpukhina N, Waite RD, Barry M, McKay IJ and Hill RG (2014). 'Smart' acid-degradable zinc-releasing silicate glasses. Materials Letters vol. 126, 278-280. 10.1016/j.matlet.2014.04.009
Näfe H, Karpukhina N, Gautam D and Näfe G (2014). Characterization of the phase mixture comprising sodium hafnate and hafnia. Zeitschrift Fur Anorganische Und Allgemeine Chemie 10.1002/zaac.201400097
Karpukhina N, Hill RG and Law RV (2014). Crystallisation in oxide glasses - a tutorial review. Chem Soc Rev vol. 43, (7) 2174-2186. 10.1039/c3cs60305a
Chen X, Chen X, Brauer DS, Wilson RM, Hill RG and Karpukhina N (2014). Bioactivity of sodium free fluoride containing glasses and glass-ceramics. Materials vol. 7, (8) 5470-5487. 10.3390/ma7085470
Chen X, Hill R and Karpukhina N (2014). Chlorapatite Glass-Ceramics. International Journal of Applied Glass Science vol. 5, (3) 207-216. 10.1111/ijag.12082
2013
Karpukhina N, Abo-Mosallam HA, Hill RG and Law RV (2013). Effect of Sodium, potassium and zinc substitutions in lithium disilicate glass and glass-ceramics. Physics and Chemistry of Glasses-European Journal of Glass Science and Technology Part B vol. 54, (2) 76-83.
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. Journal of Non-Crystalline Solids vol. 364, 85-91. 10.1016/j.jnoncrysol.2012.12.041
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal of Non-Crystalline Solids vol. 364, 92-98. 10.1016/j.jnoncrysol.2012.11.051
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II? Composite coating. Journal of Non-Crystalline Solids vol. 364, 99-106. 10.1016/j.jnoncrysol.2012.11.046
Brauer DS, Karpukhina N, Kedia G, Bhat A, Law RV, Radecka I and Hill RG (2013). Bactericidal strontium-releasing injectable bone cements based on bioactive glasses. Journal of The Royal Society Interface 10.1098/rsif.2012.0647
Mohammed NR, Kent NW, Lynch RJM, Karpukhina N, Hill R and Anderson P (2013). Effects of fluoride on in vitro enamel demineralization analyzed by ??F MAS-NMR. Caries Res vol. 47, (5) 421-428. 10.1159/000350171
2012
Zainuddin N, Karpukhina N, Law RV and Hill RG (2012). Characterisation of a remineralising Glass Carbomer (R) ionomer cement by MAS-NMR Spectroscopy. Dental Materials vol. 28, (10) 1051-1058. 10.1016/j.dental.2012.06.011
Fredholm YC, Karpukhina N, Brauer DS, Jones JR, Law RV and Hill RG (2012). Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation. Journal of The Royal Society Interface vol. 9, (70) 880-889. 10.1098/rsif.2011.0387
Lynch E, Brauer DS, Karpukhina N, Gillam DG and Hill RG (2012). Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity. Dent Mater vol. 28, (2) 168-178. 10.1016/j.dental.2011.11.021
Fujikura K, Karpukhina N, Kasuga T, Brauer DS, Hill RG and Law RV (2012). Influence of strontium substitution on structure and crystallisation of Bioglass (R) 45S5. Journal of Materials Chemistry vol. 22, (15) 7395-7402. 10.1039/c2jm14674f
2011
O'Donnell M, Hill RG, Karpukhina N and Law RV (2011). Real time neutron diffraction and NMR of the Empress II glass-ceramic system. Dental Materials vol. 27, (10) 990-996. 10.1016/j.dental.2011.06.005
2010
Brauer DS, Karpukhina N, O'Donnell MD, Law RV and Hill RG (2010). Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. Acta Biomater vol. 6, (8) 3275-3282. 10.1016/j.actbio.2010.01.043
Hill RG, O'Donnell MD, Law RV, Karpukhina N, Cochrane B and Tulyaganov D (2010). The early stages of nucleation and crystallisation of an apatite glass-ceramic: Evidence for nano-scale crystallisation. Journal of Non-Crystalline Solids vol. 356, (52-54) 2935-2941. 10.1016/j.jnoncrysol.2010.05.102
Brauer DS, Karpukhina N, Law RV and Hill RG (2010). Effect of TiO2 addition on structure, solubility and crystallisation of phosphate derived invert glasses for biomedical applications. Journal of Non-Crystalline Solids vol. 356, (44-49) 2626-2633. 10.1016/j.jnoncrysol.2010.03.022.
Abo-Mosallam HA, Hill RG, Karpukhina N and Law RV (2010). ?MAS-NMR studies of glasses and glass-ceramics based n a clinopyroxene?fluorapatite system? J. Mater. Chem vol. 20, 790-797. 10.1039/b915573b
Munhoz T, Karpukhina N, Hill RG, Law RV and De Almeida LH (2010). Setting of commercial glass ionomer cement Fuji IX by 27Al and 19F MAS-NMR. Elsevier Ltd Journal of Dentistry vol. 38, (4) 325-330. 10.1016/j.jdent.2009.12.005
2009
Zainuddin N, Karpukhina N, Hill RG and Law RV (2009). A long-term study on the setting reaction of glass ionomer cements by (27)Al MAS-NMR spectroscopy. Dent Mater vol. 25, (3) 290-295. 10.1016/j.dental.2008.07.008
Brauer DS, Karpukhina N, Law RV and Hill RG (2009). Structure of fluoride-containing bioactive glasses. J Mater Chem vol. 19, (31) 5629-5636. 10.1039/b900956f
2007
Karpukhina NG, Werner-Zwanziger U, Zwanziger JW and Kiprianov AA (2007). Preferential binding of fluorine to aluminum in high peralkaline aluminosilicate glasses. J Phys Chem B vol. 111, (35) 10413-10420. 10.1021/jp073687j
Nafe H and Karpukhina N (2007). Na-modified cubic zirconia-link between sodium zirconate and zirconia in the Na2O-ZrO2 phase diagram. J Am Ceram Soc vol. 90, (5) 1597-1602. 10.1111/j.1551-2916.2007.01616
2006
Kiprianov AA and Karpukhina NG (2006). Oxyhalide silicate glasses. Glass Physics and Chemistry vol. 32, (1) 1-27. 10.1134/S1087659606010019
2004
Kiprianov AA, Karpukhina NG and Molodozhen VA (2004). Investigation into the influence of chloride additives on the properties of alkali silicate glasses. Glass Physics and Chemistry vol. 30, (4) 325-332. 10.1023/B:GPAC.0000038704.68182.72
Kiprianov AA, Karpukhina NG and Molodozhen VA (2004). Investigation into the influence of chloride additives on the properties of alkali silicate glasses. Fizika I Khimiya Stekla vol. 30, (4) 440-451.
2001
Kiprianov AA and Karpukhina NG (2001). Influence of fluoride additions on electric characteristics of alkali silicate electrode glasses. Fizika I Khimiya Stekla vol. 27, (1) 108-116.
Karpukhina NG and Kiprianov AA (2001). Electrode properties of some fluorine-containing alkali silicate glasses. Fizika I Khimiya Stekla vol. 27, (1) 101-108.
Karpukhina NG and Kiprianov AA (2001). Electrode properties of fluorine-containing alkali silicate glasses. Glass Physics and Chemistry vol. 27, (1) 69-73. 10.1023/A:1009516005773
Kiprianov AA and Karpukhina NG (2001). Influence of fluoride additives on the electrical characteristics of alkali silicate electrode glasses. Glass Physics and Chemistry vol. 27, (1) 74-79. 10.1023/A:1009568022611
1998
Kiprianov AA, Golubko NV, Karpukhina NG and Molodozhen VA (1998). Thermal, electrical, and potentiometric characteristics of sodium aluminosilicate glasses with fluoride additives. Glass Physics and Chemistry vol. 24, (4) 350-354.
1997
Kiprianov AA and Karpukhina NG (1997). Potentiometric determination of fluoride content in alkali-aluminosilicate oxyhalide glasses. Russian Journal of Applied Chemistry vol. 70, (7) 1144-1146.
TBC
TBC