Research Interests

I am working in area of biomedical materials. I use solid-state nuclear magnetic resonance (NMR) spectroscopy to investigate structure of various glasses, cements and apatites. Solid-state NMR is extremely powerful technique to study structure of solids in particular, amorphous solids, and equally informative for crystalline solids. We study structure of bioactive silicate and phosphate glasses containing halogen and other components. We also investigate the setting reactions in various dental and bone cements including glass ionomer cements, calcium, magnesium and zinc phosphate cements using solid-state NMR. We study structure and properties of dental glass ceramics and various substitutions in apatites. Using solid-state NMR in combination with other techniques we also study structure of teeth, bones and other natural apatites. We apply our knowledge on structure of various biomaterials for designing materials for specific biomedical applications. I supervise PhD students and MSc research projects.

Key Publications

KARPUKHINA N, Gao Y and Law RV (2016). Phase Segregation in Hydroxyfluorapatite Solid Solution at High Temperatures Studied by Combined XRD/Solid State NMR. Royal Society of Chemistry  Rsc Advances  (105) 103782-103790. 10.1039/C6RA17161C

Zainuddin N, Karpukhina N, Law RV and Hill RG (2012). Characterisation of a remineralising Glass Carbomer (R) ionomer cement by MAS-NMR Spectroscopy. Dental Materials  vol. 28, (10) 1051-1058. 10.1016/j.dental.2012.06.011

Fredholm YC, Karpukhina N, Brauer DS, Jones JR, Law RV and Hill RG (2012). Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation. Journal of The Royal Society Interface  vol. 9, (70) 880-889. 10.1098/rsif.2011.0387

Fujikura K, Karpukhina N, Kasuga T, Brauer DS, Hill RG and Law RV (2012). Influence of strontium substitution on structure and crystallisation of Bioglass (R) 45S5. Journal of Materials Chemistry  vol. 22, (15) 7395-7402. 10.1039/c2jm14674f

Brauer DS, Karpukhina N, O'Donnell MD, Law RV and Hill RG (2010). Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. Acta Biomater  vol. 6, (8) 3275-3282. 10.1016/j.actbio.2010.01.043

2018

Duminis T, Shahid S, Karpukhina NG and Hill RG (2018). Predicting refractive index of fluoride containing glasses for aesthetic dental restorations. Dent Mater  vol. 34, (5) e83-e88. 10.1016/j.dental.2018.01.024

Pedone A, Chen X, Hill RG and Karpukhina N (2018). Molecular Dynamics Investigation of Halide-Containing Phospho-Silicate Bioactive Glasses. J Phys Chem B  vol. 122, (11) 2940-2948. 10.1021/acs.jpcb.8b00547

Kanwal N, Brauer DS, Earl J, Wilson RM, Karpukhina N and Hill RG (2018). In-vitro apatite formation capacity of a bioactive glass - containing toothpaste. J Dent  vol. 68, 51-58. 10.1016/j.jdent.2017.10.015

Simila HO, Karpukhina N and Hill RG (2018). Bioactivity and fluoride release of strontium and fluoride modified Biodentine. Dent Mater  vol. 34, (1) e1-e7. 10.1016/j.dental.2017.10.005

Kent NW, Blunn G, Karpukhina N, Davis G, de Godoy RF, Wilson RM, Coathup M, Onwordi L, Quak WY and Hill R (2018). In vitro and in vivo study of commercial calcium phosphate cement HydroSet?. J Biomed Mater Res B Appl Biomater  vol. 106, (1) 21-30. 10.1002/jbm.b.33809

2017

KARPUKHINA N, Chen X, Chen X, Brauer DS, Wilson RM, Law RV and Hill RG (2017). Sodium is not essential for high bioactivity of glasses. Wiley  International Journal of Applied Glass Science  10.1111/ijag.12323

Swansbury LA, Mountjoy G, Chen X, Karpukhina N and Hill R (2017). Modeling the Onset of Phase Separation in CaO-SiO2-CaCl2 Chlorine-Containing Silicate Glasses. J Phys Chem B  vol. 121, (22) 5647-5653. 10.1021/acs.jpcb.7b02986

Chen X, Karpukhina N, Brauer DS and Hill RG (2017). High chloride content calcium silicate glasses. Phys Chem Chem Phys  vol. 19, (10) 7078-7085. 10.1039/c6cp07905a

2016

KARPUKHINA N, Gao Y and Law RV (2016). Phase Segregation in Hydroxyfluorapatite Solid Solution at High Temperatures Studied by Combined XRD/Solid State NMR. Royal Society of Chemistry  Rsc Advances  (105) 103782-103790. 10.1039/C6RA17161C

Kusumoto H, Abolghasemi S, Woodfine B, Hill RG, Karpukhina N and Law RV (2016). The effect of phosphate, fluorine, and soda content of the glass on the mechanical properties of the glass ionomer (polyalkenoate) cements. Journal of Non-Crystalline Solids  vol. 449, 94-99. 10.1016/j.jnoncrysol.2016.06.036

Kent NW, Hill RG and Karpukhina N (2016). A new way of forming a calcium phosphate cement using bioactive glasses as a reactive precursor. Materials Letters  vol. 162, 32-36. 10.1016/j.matlet.2015.09.099

2015

Al Mansour F, Karpukhina N, Grasso S, Wilson RM, Reece MJ and Cattell MJ (2015). The effect of spark plasma sintering on lithium disilicate glass-ceramics. Dent Mater  vol. 31, (10) e226-e235. 10.1016/j.dental.2015.07.001

Bingel L, Groh D, Karpukhina N and Brauer DS (2015). Influence of dissolution medium pH on ion release and apatite formation of Bioglass? 45S5. Materials Letters  vol. 143, 279-282. 10.1016/j.matlet.2014.12.124

Tang HM, Shahid S, Karpukhina N, Law RV and Hill RG (2015). Glass polyalkenoate cements based on simple CaO-Al2O3-SiO2 glasses. Materials Science and Technology (United Kingdom)  vol. 31, (2) 197-202. 10.1179/1743284714Y.0000000601

Chen X, Karpukhina N, Brauer DS and Hill RG (2015). Novel highly degradable chloride containing bioactive glasses. Biomedical Glasses  vol. 1, (1) 108-118. 10.1515/bglass-2015-0010

Kanwal N, Toms H, Hannon AC, Perras FA, Bryce DL, Karpukhina N and Abrahams I (2015). Structure and solubility behaviour of zinc containing phosphate glasses. Journal of Materials Chemistry B  vol. 3, (45) 8842-8855. 10.1039/c4tb01504e

2014

CATTELL MJ, Karpukhina N and Almuhamadi J (2014). Diopside Glass-Ceramics for Dental and Biomedical Applications. Advances in Science and Technology.  vol. 96, 10.4028/www.scientific.net/AST.96.15

Chen X, Chen X, Brauer DS, Wilson RM, Hill RG and Karpukhina N (2014). Novel alkali free bioactive fluorapatite glass ceramics. Journal of Non-Crystalline Solids  vol. 402, 172-177. 10.1016/j.jnoncrysol.2014.05.025

Chen X, Brauer DS, Karpukhina N, Waite RD, Barry M, McKay IJ and Hill RG (2014). 'Smart' acid-degradable zinc-releasing silicate glasses. Materials Letters  vol. 126, 278-280. 10.1016/j.matlet.2014.04.009

Näfe H, Karpukhina N, Gautam D and Näfe G (2014). Characterization of the phase mixture comprising sodium hafnate and hafnia. Zeitschrift Fur Anorganische Und Allgemeine Chemie  10.1002/zaac.201400097

Karpukhina N, Hill RG and Law RV (2014). Crystallisation in oxide glasses - a tutorial review. Chem Soc Rev  vol. 43, (7) 2174-2186. 10.1039/c3cs60305a

Chen X, Chen X, Brauer DS, Wilson RM, Hill RG and Karpukhina N (2014). Bioactivity of sodium free fluoride containing glasses and glass-ceramics. Materials  vol. 7, (8) 5470-5487. 10.3390/ma7085470

Chen X, Hill R and Karpukhina N (2014). Chlorapatite Glass-Ceramics. International Journal of Applied Glass Science  vol. 5, (3) 207-216. 10.1111/ijag.12082

2013

Karpukhina N, Abo-Mosallam HA, Hill RG and Law RV (2013). Effect of Sodium, potassium and zinc substitutions in lithium disilicate glass and glass-ceramics. Physics and Chemistry of Glasses-European Journal of Glass Science and Technology Part B  vol. 54, (2) 76-83.

Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. Journal of Non-Crystalline Solids  vol. 364, 85-91. 10.1016/j.jnoncrysol.2012.12.041

Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal of Non-Crystalline Solids  vol. 364, 92-98. 10.1016/j.jnoncrysol.2012.11.051

Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II? Composite coating. Journal of Non-Crystalline Solids  vol. 364, 99-106. 10.1016/j.jnoncrysol.2012.11.046

Mohammed NR, Kent NW, Lynch RJM, Karpukhina N, Hill R and Anderson P (2013). Effects of fluoride on in vitro enamel demineralization analyzed by ??F MAS-NMR. Caries Res  vol. 47, (5) 421-428. 10.1159/000350171

Brauer DS, Karpukhina N, Kedia G, Bhat A, Law RV, Radecka I and Hill RG (2013). Bactericidal strontium-releasing injectable bone cements based on bioactive glasses. Journal of The Royal Society Interface  10.1098/rsif.2012.0647

2012

Zainuddin N, Karpukhina N, Law RV and Hill RG (2012). Characterisation of a remineralising Glass Carbomer (R) ionomer cement by MAS-NMR Spectroscopy. Dental Materials  vol. 28, (10) 1051-1058. 10.1016/j.dental.2012.06.011

Fredholm YC, Karpukhina N, Brauer DS, Jones JR, Law RV and Hill RG (2012). Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation. Journal of The Royal Society Interface  vol. 9, (70) 880-889. 10.1098/rsif.2011.0387

Lynch E, Brauer DS, Karpukhina N, Gillam DG and Hill RG (2012). Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity. Dent Mater  vol. 28, (2) 168-178. 10.1016/j.dental.2011.11.021

Fujikura K, Karpukhina N, Kasuga T, Brauer DS, Hill RG and Law RV (2012). Influence of strontium substitution on structure and crystallisation of Bioglass (R) 45S5. Journal of Materials Chemistry  vol. 22, (15) 7395-7402. 10.1039/c2jm14674f

2011

O'Donnell M, Hill RG, Karpukhina N and Law RV (2011). Real time neutron diffraction and NMR of the Empress II glass-ceramic system. Dental Materials  vol. 27, (10) 990-996. 10.1016/j.dental.2011.06.005

2010

Brauer DS, Karpukhina N, O'Donnell MD, Law RV and Hill RG (2010). Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. Acta Biomater  vol. 6, (8) 3275-3282. 10.1016/j.actbio.2010.01.043

Hill RG, O'Donnell MD, Law RV, Karpukhina N, Cochrane B and Tulyaganov D (2010). The early stages of nucleation and crystallisation of an apatite glass-ceramic: Evidence for nano-scale crystallisation. Journal of Non-Crystalline Solids  vol. 356, (52-54) 2935-2941. 10.1016/j.jnoncrysol.2010.05.102

Brauer DS, Karpukhina N, Law RV and Hill RG (2010). Effect of TiO2 addition on structure, solubility and crystallisation of phosphate derived invert glasses for biomedical applications. Journal of Non-Crystalline Solids  vol. 356, (44-49) 2626-2633. 10.1016/j.jnoncrysol.2010.03.022.

Abo-Mosallam HA, Hill RG, Karpukhina N and Law RV (2010). ?MAS-NMR studies of glasses and glass-ceramics based n a clinopyroxene?fluorapatite system? J. Mater. Chem.  vol. 20, 790-797. 10.1039/b915573b

Munhoz T, Karpukhina N, Hill RG, Law RV and De Almeida LH (2010). Setting of commercial glass ionomer cement Fuji IX by 27Al and 19F MAS-NMR. Elsevier Ltd  Journal of Dentistry  vol. 38, (4) 325-330. 10.1016/j.jdent.2009.12.005

2009

Zainuddin N, Karpukhina N, Hill RG and Law RV (2009). A long-term study on the setting reaction of glass ionomer cements by (27)Al MAS-NMR spectroscopy. Dent Mater  vol. 25, (3) 290-295. 10.1016/j.dental.2008.07.008

Brauer DS, Karpukhina N, Law RV and Hill RG (2009). Structure of fluoride-containing bioactive glasses. J Mater Chem  vol. 19, (31) 5629-5636. 10.1039/b900956f

2007

Karpukhina NG, Werner-Zwanziger U, Zwanziger JW and Kiprianov AA (2007). Preferential binding of fluorine to aluminum in high peralkaline aluminosilicate glasses. J Phys Chem B  vol. 111, (35) 10413-10420. 10.1021/jp073687j

Nafe H and Karpukhina N (2007). Na-modified cubic zirconia-link between sodium zirconate and zirconia in the Na2O-ZrO2 phase diagram. J Am Ceram Soc  vol. 90, (5) 1597-1602. 10.1111/j.1551-2916.2007.01616

2006

Kiprianov AA and Karpukhina NG (2006). Oxyhalide silicate glasses. Glass Physics and Chemistry  vol. 32, (1) 1-27. 10.1134/S1087659606010019

2004

Kiprianov AA, Karpukhina NG and Molodozhen VA (2004). Investigation into the influence of chloride additives on the properties of alkali silicate glasses. Glass Physics and Chemistry  vol. 30, (4) 325-332. 10.1023/B:GPAC.0000038704.68182.72

Kiprianov AA, Karpukhina NG and Molodozhen VA (2004). Investigation into the influence of chloride additives on the properties of alkali silicate glasses. Fizika I Khimiya Stekla  vol. 30, (4) 440-451.

2001

Kiprianov AA and Karpukhina NG (2001). Influence of fluoride additions on electric characteristics of alkali silicate electrode glasses. Fizika I Khimiya Stekla  vol. 27, (1) 108-116.

Karpukhina NG and Kiprianov AA (2001). Electrode properties of some fluorine-containing alkali silicate glasses. Fizika I Khimiya Stekla  vol. 27, (1) 101-108.

Kiprianov AA and Karpukhina NG (2001). Influence of fluoride additives on the electrical characteristics of alkali silicate electrode glasses. Glass Physics and Chemistry  vol. 27, (1) 74-79. 10.1023/A:1009568022611

Karpukhina NG and Kiprianov AA (2001). Electrode properties of fluorine-containing alkali silicate glasses. Glass Physics and Chemistry  vol. 27, (1) 69-73. 10.1023/A:1009516005773

1998

Kiprianov AA, Golubko NV, Karpukhina NG and Molodozhen VA (1998). Thermal, electrical, and potentiometric characteristics of sodium aluminosilicate glasses with fluoride additives. Glass Physics and Chemistry  vol. 24, (4) 350-354.

1997

Kiprianov AA and Karpukhina NG (1997). Potentiometric determination of fluoride content in alkali-aluminosilicate oxyhalide glasses. Russian Journal of Applied Chemistry  vol. 70, (7) 1144-1146.

TBC

TBC