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Dr Natalia Karpukhina

Natalia Karpukhina

Senior Lecturer

Institute of Dentistry
Dental Physical Sciences Unit, 2nd Fl. Francis Bancroft Building, Mile End
+44 (0)20 7882 5975

www.materials.qmul.ac.uk/people/?n.karpukhina

Research

Research Interests

I am working in area of biomedical materials. I use solid-state nuclear magnetic resonance (NMR) spectroscopy to investigate structure of various glasses, cements and apatites. Solid-state NMR is extremely powerful technique to study structure of solids in particular, amorphous solids, and equally informative for crystalline solids. We study structure of bioactive silicate and phosphate glasses containing halogen and other components. We also investigate the setting reactions in various dental and bone cements including glass ionomer cements, calcium, magnesium and zinc phosphate cements using solid-state NMR. We study structure and properties of dental glass ceramics and various substitutions in apatites. Using solid-state NMR in combination with other techniques we also study structure of teeth, bones and other natural apatites. We apply our knowledge on structure of various biomaterials for designing materials for specific biomedical applications. I supervise PhD students and MSc research projects.

Publications of specific relevance to Materials Research

Publications

2021

  • Henry J, Rashwan M, Karpukhina N and Hill RG (2021). Influence of Fluorine Content on the Crystallisation of Potassium and Barium Fluorphlogopite Glass-Ceramics. Elsevier Bv  Journal of Non-Crystalline Solids  vol. 559, 120680-120680. 10.1016/j.jnoncrysol.2021.120680

2020

2019

  • Baysan A, Sleibi A, Tappuni A, Karpukhina N and Hill R (2019). A Comparative Evaluation of Ion Release Characteristics of Three Different Dental Varnishes containing Fluoride either with CPP-ACP or Bioactive glass. Elsevier  Dental Materials  10.1016/j.dental.2019.08.113
  • Al-eesa NA, KARPUKHINA N, HILL RG, JOHAL A and WONG FSL (2019). Bioactive glass composite for orthodontic adhesives – formation and characterisation of apatites using MAS-NMR and SEM. Elsevier  Dental Materials  10.1016/j.dental.2019.02.010
  • Kusumoto H, HILL RG, KARPUKHINA N and Law RV (2019). Magnesium substitution in calcium and strontium fluoro-phospho-aluminosilicate glasses by multinuclear 19F, 31P, 27Al, and 29Si MAS-NMR spectroscopy. Journal of Non-Crystalline Solids X  10.1016/j.nocx.2019.100008

2018

  • AL-KHAFAJI TJ, WONG F, FLEMING PS, KARPUKHINA N and HILL R (2018). Novel fluoride and strontium-containing bioactive glasses for dental varnishes-design and bioactivity in Tris buffer solution. Elsevier  Journal of Non-Crystalline Solids  vol. 503-504, 120-130. 10.1016/j.jnoncrysol.2018.09.037
  • Uwalaka C, KARPUKHINA N, CAO X, Bissasu S, WILSON R and CATTELL MJ (2018). Effect of Sandblasting, Etching and Resin bonding on the Flexural Strength/Bonding of Novel Glass-Ceramics. Elsevier  Dental Materials Journal  10.1016/j.dental.2018.07.001
  • DUMINIS T, Shahid S, KARPUKHINA N and HILL R (2018). Predicting Refractive Index of Fluoride Containing Glasses For Aesthetic Dental Restorations. Dental Materials  10.1016/j.dental.2018.01.024
  • Pedone A, Chen X, Hill RG and Karpukhina N (2018). Molecular Dynamics Investigation of Halide-Containing Phospho-Silicate Bioactive Glasses. J Phys Chem B  vol. 122, (11) 2940-2948. 10.1021/acs.jpcb.8b00547
  • CHEN X, Pedone A, Apperley D, HILL R and KARPUKHINA N (2018). New insight into mixing fluoride and chloride in bioactive silicate glasses. Nature Publishing Group  Scientific Reports  vol. 8, 1316-1316. 10.1038/s41598-018-19544-2
  • Kent NW, Blunn G, Karpukhina N, Davis G, de Godoy RF, Wilson RM, Coathup M, Onwordi L, Quak WY and Hill R (2018). In vitro and in vivo study of commercial calcium phosphate cement HydroSet™. Journal of Biomedical Materials Research - Part B Applied Biomaterials  vol. 106, (1) 21-30. 10.1002/jbm.b.33809
  • Simila HO, Karpukhina N and Hill RG (2018). Bioactivity and fluoride release of strontium and fluoride modified Biodentine. Dental Materials  vol. 34, (1) e1-e7. 10.1016/j.dental.2017.10.005
  • Kanwal N, Brauer DS, Earl J, Wilson RM, Karpukhina N and Hill RG (2018). In-vitro apatite formation capacity of a bioactive glass - containing toothpaste. Journal of Dentistry  vol. 68, 51-58. 10.1016/j.jdent.2017.10.015

2017

  • KARPUKHINA N, Chen X, Brauer DS, Wilson RM, Law RV and Hill RG (2017). Sodium is not essential for high bioactivity of glasses. Wiley  International Journal of Applied Glass Science  10.1111/ijag.12323
  • Swansbury LA, Mountjoy G, Chen X, Karpukhina N and Hill R (2017). Modeling the Onset of Phase Separation in CaO-SiO2-CaCl2 Chlorine-Containing Silicate Glasses. J Phys Chem B  vol. 121, (22) 5647-5653. 10.1021/acs.jpcb.7b02986
  • Chen X, Karpukhina N, Brauer DS and Hill RG (2017). High chloride content calcium silicate glasses. Phys Chem Chem Phys  vol. 19, (10) 7078-7085. 10.1039/c6cp07905a

2016

  • KARPUKHINA N, Gao Y and Law RV (2016). Phase Segregation in Hydroxyfluorapatite Solid Solution at High Temperatures Studied by Combined XRD/Solid State NMR. Royal Society of Chemistry  Rsc Advances  (105) 103782-103790. 10.1039/C6RA17161C
  • Kusumoto H, Abolghasemi S, Woodfine B, Hill RG, Karpukhina N and Law RV (2016). The effect of phosphate, fluorine, and soda content of the glass on the mechanical properties of the glass ionomer (polyalkenoate) cements. Journal of Non-Crystalline Solids  vol. 449, 94-99. 10.1016/j.jnoncrysol.2016.06.036
  • Kent NW, Hill RG and Karpukhina N (2016). A new way of forming a calcium phosphate cement using bioactive glasses as a reactive precursor. Materials Letters  vol. 162, 32-36. 10.1016/j.matlet.2015.09.099

2015

2014

2013

  • Karpukhina N, Abo-Mosallam HA, Hill RG and Law RV (2013). Effect of Sodium, potassium and zinc substitutions in lithium disilicate glass and glass-ceramics. Physics and Chemistry of Glasses-European Journal of Glass Science and Technology Part B  vol. 54, (2) 76-83.
  • Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. Journal of Non-Crystalline Solids  vol. 364, 85-91. 10.1016/j.jnoncrysol.2012.12.041
  • Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II— Composite coating. Journal of Non-Crystalline Solids  vol. 364, 99-106. 10.1016/j.jnoncrysol.2012.11.046
  • Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal of Non-Crystalline Solids  vol. 364, 92-98. 10.1016/j.jnoncrysol.2012.11.051
  • Brauer DS, Karpukhina N, Kedia G, Bhat A, Law RV, Radecka I and Hill RG (2013). Bactericidal strontium-releasing injectable bone cements based on bioactive glasses. Journal of The Royal Society Interface  10.1098/rsif.2012.0647
  • Mohammed NR, Kent NW, Lynch RJM, Karpukhina N, Hill R and Anderson P (2013). Effects of fluoride on in vitro enamel demineralization analyzed by ¹⁹F MAS-NMR. Caries Res  vol. 47, (5) 421-428. 10.1159/000350171

2012

  • Zainuddin N, Karpukhina N, Law RV and Hill RG (2012). Characterisation of a remineralising Glass Carbomer (R) ionomer cement by MAS-NMR Spectroscopy. Dental Materials  vol. 28, (10) 1051-1058. 10.1016/j.dental.2012.06.011
  • Fredholm YC, Karpukhina N, Brauer DS, Jones JR, Law RV and Hill RG (2012). Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation. Journal of The Royal Society Interface  vol. 9, (70) 880-889. 10.1098/rsif.2011.0387
  • Lynch E, Brauer DS, Karpukhina N, Gillam DG and Hill RG (2012). Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity. Dent Mater  vol. 28, (2) 168-178. 10.1016/j.dental.2011.11.021
  • Fujikura K, Karpukhina N, Kasuga T, Brauer DS, Hill RG and Law RV (2012). Influence of strontium substitution on structure and crystallisation of Bioglass (R) 45S5. Journal of Materials Chemistry  vol. 22, (15) 7395-7402. 10.1039/c2jm14674f

2011

  • (2011). Real time neutron diffraction and NMR of the Empress II glass-ceramic system. Dental Materials  vol. 27, (10) 990-996. 10.1016/j.dental.2011.06.005

2010

  • (2010). Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid. Acta Biomater  vol. 6, (8) 3275-3282. 10.1016/j.actbio.2010.01.043
  • Munhoz T, Karpukhina N, Hill RG, Law RV and De Almeida LH (2010). Setting of commercial glass ionomer cement Fuji IX by 27Al and 19F MAS-NMR. Elsevier Ltd  Journal of Dentistry  vol. 38, (4) 325-330. 10.1016/j.jdent.2009.12.005
  • Abo-Mosallam HA, Hill RG, Karpukhina N and Law RV (2010). MAS-NMR studies of glasses and glass-ceramics based on a clinopyroxene-fluorapatite system. Royal Society of Chemistry  Journal of Materials Chemistry  vol. 20, (4) 790-797. 10.1039/b915573b
  • (2010). The early stages of nucleation and crystallisation of an apatite glass-ceramic: Evidence for nano-scale crystallisation. Journal of Non-Crystalline Solids  vol. 356, (52-54) 2935-2941. 10.1016/j.jnoncrysol.2010.05.102
  • Brauer DS, Karpukhina N, Law RV and Hill RG (2010). Effect of TiO2 addition on structure, solubility and crystallisation of phosphate derived invert glasses for biomedical applications. Journal of Non-Crystalline Solids  vol. 356, (44-49) 2626-2633. 10.1016/j.jnoncrysol.2010.03.022.

2009

2007

  • Karpukhina NG, Werner-Zwanziger U, Zwanziger JW and Kiprianov AA (2007). Preferential binding of fluorine to aluminum in high pecalkaline aluminosilicate glasses. Journal of Physical Chemistry B  vol. 111, (35) 10413-10420. 10.1021/jp073687j
  • Nafe H and Karpukhina N (2007). Na-modified cubic zirconia-link between sodium zirconate and zirconia in the Na2O-ZrO2 phase diagram. J Am Ceram Soc  vol. 90, (5) 1597-1602. 10.1111/j.1551-2916.2007.01616

2006

2004

  • Kiprianov AA, Karpukhina NG and Molodozhen VA (2004). Investigation into the influence of chloride additives on the properties of alkali silicate glasses. Glass Physics and Chemistry  vol. 30, (4) 325-332. 10.1023/B:GPAC.0000038704.68182.72
  • Kiprianov AA, Karpukhina NG and Molodozhen VA (2004). Investigation into the influence of chloride additives on the properties of alkali silicate glasses. Fizika I Khimiya Stekla  vol. 30, (4) 440-451.

2001

  • Karpukhina NG and Kiprianov AA (2001). Electrode properties of some fluorine-containing alkali silicate glasses. Fizika I Khimiya Stekla  vol. 27, (1) 101-108.
  • Kiprianov AA and Karpukhina NG (2001). Influence of fluoride additions on electric characteristics of alkali silicate electrode glasses. Fizika I Khimiya Stekla  vol. 27, (1) 108-116.
  • Kiprianov AA and Karpukhina NG (2001). Influence of fluoride additives on the electrical characteristics of alkali silicate electrode glasses. Glass Physics and Chemistry  vol. 27, (1) 74-79. 10.1023/A:1009568022611
  • Karpukhina NG and Kiprianov AA (2001). Electrode properties of fluorine-containing alkali silicate glasses. Glass Physics and Chemistry  vol. 27, (1) 69-73. 10.1023/A:1009516005773

1998

  • Kiprianov AA, Golubko NV, Karpukhina NG and Molodozhen VA (1998). Thermal, electrical, and potentiometric characteristics of sodium aluminosilicate glasses with fluoride additives. Glass Physics and Chemistry  vol. 24, (4) 350-354.

1997

  • Kiprianov AA and Karpukhina NG (1997). Potentiometric determination of fluoride content in alkali-aluminosilicate oxyhalide glasses. Russian Journal of Applied Chemistry  vol. 70, (7) 1144-1146.