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Materials Research Institute

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Dr Stellios Arseniyadis

Reader in Organic Chemistry /

Department School of Biological and Chemical Sciences
 Room G.08, Joseph Priestley Building
Telephone +44 (0)20 7882 8445
Email s.arseniyadis@qmul.ac.uk
Homepage http://www.sbcs.qmul.ac.uk/staff/stelliosarseniyadis.html

Research Keywords

Organic Chemistry

Research Interests

I am principally interested in the development of new synthetic methods to attain high structural and functional complexity. Methods lie within the areas of organocatalysis, transition metal catalysis and, more recently, bio-hybrid catalysis. In addition to that, I am interested in developing new drug-delivery devices by combining acoustics and microfluidics.

Find out more on our website

Research department

Chemistry and Biochemistry

Key Publications

ARSENIYADIS S, DUCHEMIN N, Skiredj A, Mansot J, Leblanc K, Vasseur J-J, Beniddir M, Evanno E, Poupon E and Smietana M (2018). DNA-Templated [2 2] Photocycloaddition: A Straightforward Entry into the Aplysinopsin Family of Natural Products. Wiley  Angewandte Chemie International Edition  10.1002/anie.201806357

Benedetti E, Duchemin N, Bethge L, Vonhoff S, Klussmann S, Vasseur J-J, Cossy J, Smietana M and Arseniyadis S (2015). DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis. Chem. Commun.  vol. 51, (28) 6076-6079. 10.1039/C4CC10190A

Bezagu M, Errico C, Chaulot-Talmon V, Monti F, Tanter M, Tabeling P, Cossy J, Arseniyadis S and Couture O (2014). High Spatiotemporal Control of Spontaneous Reactions Using Ultrasound-Triggered Composite Droplets. Journal of The American Chemical Society  vol. 136, (20) 7205-7208. 10.1021/ja5019354

Wang J, Benedetti E, Bethge L, Vonhoff S, Klussmann S, Vasseur J-J, Cossy J, Smietana M and Arseniyadis S (2013). DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis. Angewandte Chemie International Edition  vol. 52, (44) 11546-11549. 10.1002/anie.201306232

Arseniyadis S, Fournier J, Thangavelu S, Lozano O, Prevost S, Archambeau A, Menozzi C and Cossy J (2013). Palladium-Catalyzed Allylic Alkylation of Allyl Dienol Carbonates: Reactivity, Regioselectivity, Enantioselectivity, and Synthetic Applications. Synlett  vol. 24, (18) 2350-2364. 10.1055/s-0033-1338987

2018

ARSENIYADIS S and Smietana M (2018). Challenges and Opportunities in DNA-based Asymmetric Catalysis. Schweizerische Chemische Gesellschaft  Chimia  10.2533/chimia.2018.630

ARSENIYADIS S, DUCHEMIN N, Skiredj A, Mansot J, Leblanc K, Vasseur J-J, Beniddir M, Evanno E, Poupon E and Smietana M (2018). DNA-Templated [2 2] Photocycloaddition: A Straightforward Entry into the Aplysinopsin Family of Natural Products. Wiley  Angewandte Chemie International Edition  10.1002/anie.201806357

ARSENIYADIS S, Song T and Cossy J (2018). Highly Enantioselective, Base-Free Synthesis of ?-Quaternary Succinimides through Catalytic Asymmetric Allylic Alkylation. Wiley  Chemistry - a European Journal  10.1002/chem.201800920

ARSENIYADIS S (2018). Palladium-catalyzed asymmetric allylic alkylation of 4-substituted isoxazolidin-5-ones: A straightforward access to b2,2-amino acids. Wiley  Chemistry - a European Journal  10.1002/chem.201800641

ARSENIYADIS S (2018). Dinucleating Schiff base ligand in Zn/4f coordination chemistry: synthetic challenges and catalytic activity evaluation. Royal Society of Chemistry  Dalton Transactions  10.1039/C8DT00538A

2017

Dolé Kerim M, Cattoen M, Fincias N, Dos Santos A, Arseniyadis S and El Kaim L (2017). Palladium-catalysed O-Allylation of ?-Hydroxyphosphonates: An Expedient entry into Phosphono-oxaheterocycles. Advanced Synthesis & Catalysis  10.1002/adsc.201701150

Duchemin N, Heath-Apostolopoulos I, Smietana M and Arseniyadis S (2017). A decade of DNA-hybrid catalysis: from innovation to comprehension. Org. Biomol. Chem.  vol. 15, (34) 7072-7087. 10.1039/C7OB00176B

Bezagu M, Clarhaut J, Renoux B, Monti F, Tanter M, Tabeling P, Cossy J, Couture O, Papot S and Arseniyadis S (2017). In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets. European Journal of Medicinal Chemistry  10.1016/j.ejmech.2017.03.057

Nascimento de Oliveira M, Fournier J, Arseniyadis S and Cossy J (2017). A Palladium-Catalyzed Asymmetric Allylic Alkylation Approach to ?-Quaternary ?-Butyrolactones. Organic Letters  vol. 19, (1) 14-17. 10.1021/acs.orglett.6b02971

2016

El Mamouni EH, Cattoen M, Cordier M, Cossy J, Arseniyadis S, Ilitki H and El Kaïm L (2016). Selective Tsuji?Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles. Chem. Commun.  vol. 52, (100) 14490-14493. 10.1039/C6CC08171A

Kolleth A, Gebauer J, ElMarrouni A, Lebeuf R, Prévost C, Brohan E, Arseniyadis S and Cossy J (2016). Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon. Frontiers Media  Frontiers in Chemistry  vol. 4, 10.3389/fchem.2016.00034

ARSENIYADIS S, Bressy C, Smietana M and Benedetti E (2016). Acetate Biosynthetic Pathway - Polyketides. From Biosynthesis to Total Synthesis Strategies and Tactics For Natural Products  John Wiley & Sons 

Amirbekyan K, Duchemin N, Benedetti E, Joseph R, Colon A, Markarian SA, Bethge L, Vonhoff S, Klussmann S, Cossy J, Vasseur J-J, Arseniyadis S and Smietana M (2016). Design, Synthesis, and Binding Affinity Evaluation of Hoechst 33258 Derivatives for the Development of Sequence-Specific DNA-Based Asymmetric Catalysts. American Chemical Society  Acs Catalysis  3096-3105. 10.1021/acscatal.6b00495

Duchemin N, Benedetti E, Bethge L, Vonhoff S, Klussmann S, Vasseur J-J, Cossy J, Smietana M and Arseniyadis S (2016). Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA. Chem. Commun.  vol. 52, (55) 8604-8607. 10.1039/C6CC03540J

2015

Benedetti E, Duchemin N, Bethge L, Vonhoff S, Klussmann S, Vasseur J-J, Cossy J, Smietana M and Arseniyadis S (2015). DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis. Chem. Commun.  vol. 51, (28) 6076-6079. 10.1039/C4CC10190A

Bezagu M, Arseniyadis S, Cossy J, Couture O, Tanter M, Monti F and Tabeling P (2015). A fast and switchable microfluidic mixer based on ultrasound-induced vaporization of perfluorocarbon. Lab Chip  vol. 15, (9) 2025-2029. 10.1039/C5LC00247H

2014

Barbeyron R, Benedetti E, Cossy J, Vasseur J-J, Arseniyadis S and Smietana M (2014). Recent developments in alkyne borylations. Tetrahedron  vol. 70, (45) 8431-8452. 10.1016/j.tet.2014.06.026

Bezagu M, Errico C, Chaulot-Talmon V, Monti F, Tanter M, Tabeling P, Cossy J, Arseniyadis S and Couture O (2014). High Spatiotemporal Control of Spontaneous Reactions Using Ultrasound-Triggered Composite Droplets. Journal of The American Chemical Society  vol. 136, (20) 7205-7208. 10.1021/ja5019354

2013

ARSENIYADIS S and Spivey AC (2013). Regio- and Position Selective Reactions and Desymmetrizations. Comprehensive Enantioselective Organocatalysis Catalysts, Reactions, and Applications, 3 Volume Set  Wiley-Vch 

El Marrouni A, Kolleth A, Lebeuf R, Gebauer J, Prevost S, Heras M, Arseniyadis S and Cossy J (2013). ChemInform Abstract: Lyngbouilloside and Related Macrolides from Marine Cyanobacteria. Cheminform  vol. 44, (49) no-no. 10.1002/chin.201349234

Wang J, Benedetti E, Bethge L, Vonhoff S, Klussmann S, Vasseur J-J, Cossy J, Smietana M and Arseniyadis S (2013). DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis. Angewandte Chemie International Edition  vol. 52, (44) 11546-11549. 10.1002/anie.201306232

Arseniyadis S, Fournier J, Thangavelu S, Lozano O, Prevost S, Archambeau A, Menozzi C and Cossy J (2013). Palladium-Catalyzed Allylic Alkylation of Allyl Dienol Carbonates: Reactivity, Regioselectivity, Enantioselectivity, and Synthetic Applications. Synlett  vol. 24, (18) 2350-2364. 10.1055/s-0033-1338987

Kolleth A, Cattoen M, Arseniyadis S and Cossy J (2013). Non-enzymatic acylative kinetic resolution of primary allylic amines. Chem Commun (Camb)  vol. 49, (81) 9338-9340. 10.1039/c3cc45453c

Smietana M, Vasseur J-J, Cossy J and Arseniyadis S (2013). ChemInform Abstract: DNA as a Tool for Molecular Discovery. Cheminform  vol. 44, (30) no-no. 10.1002/chin.201330243

Fournier J, Lozano O, Menozzi C, Arseniyadis S and Cossy J (2013). Palladium-Catalyzed Asymmetric Allylic Alkylation of Cyclic Dienol Carbonates: Efficient Route to Enantioenriched ?-Butenolides Bearing an All-Carbon ?-Quaternary Stereogenic Center. Angewandte Chemie  vol. 125, (4) 1295-1299. 10.1002/ange.201206368

2012

ARSENIYADIS S, Cossy J, Smietana M and Vasseur J-J (2012). DNA as a Tool for Molecular Discovery. Modern Tools For The Synthesis of Complex Bioactive Molecules  John Wiley & Sons 

Cossy J and Arseniyadis S (2012). Modern Tools for the Synthesis of Complex Bioactive Molecules. John Wiley & Sons 

Fournier J, Arseniyadis S and Cossy J (2012). A Modular and Scalable One-Pot Synthesis of Polysubstituted Furans. Angewandte Chemie International Edition  vol. 51, (30) 7562-7566. 10.1002/anie.201202486

ElMarrouni A, Lebeuf R, Gebauer J, Heras M, Arseniyadis S and Cossy J (2012). Total Synthesis of Nominal Lyngbouilloside Aglycon. Organic Letters  vol. 14, (1) 314-317. 10.1021/ol203064r

Colon A, Hoffman TJ, Gebauer J, Dash J, Rigby JH, Arseniyadis S and Cossy J (2012). Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F. Chemical Communications  vol. 48, (85) 10508-10508. 10.1039/c2cc35721f

Kolleth A, Christoph S, Arseniyadis S and Cossy J (2012). Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process. Chemical Communications  vol. 48, (85) 10511-10511. 10.1039/c2cc35719d

2011

Cossy J, Arseniyadis S and Meyer C (2011). Metathesis in Natural Product Synthesis Strategies, Substrates and Catalysts. John Wiley & Sons 

Dash J, Melillo B, Arseniyadis S and Cossy J (2011). A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles. Tetrahedron Letters  vol. 52, (17) 2246-2249. 10.1016/j.tetlet.2011.01.027

Arseniyadis S, Mahesh M, McDaid P, Hampel T, Davey SG and Spivey AC (2011). Studies towards the N-acylative kinetic resolution of NOBIN. Collection of Czechoslovak Chemical Communications  vol. 76, (10) 1239-1253. 10.1135/cccc2011034

2010

ElMarrouni A, Fukuda A, Heras M, Arseniyadis S and Cossy J (2010). Expedient Synthesis of a Stereoisomer of Acremolide B ? The Journal of Organic Chemistry  vol. 75, (24) 8478-8486. 10.1021/jo1017487

ElMarrouni A, Joolakanti SR, Colon A, Heras M, Arseniyadis S and Cossy J (2010). Two Concise Total Syntheses of (-)-Bitungolide F. Organic Letters  vol. 12, (18) 4074-4077. 10.1021/ol101659y

Hoffman TJ, Kolleth A, Rigby JH, Arseniyadis S and Cossy J (2010). Stereoselective Synthesis of the C1-C11 and C12-C34 Fragments of Mycalolide A. Organic Letters  vol. 12, (15) 3348-3351. 10.1021/ol101145t

Nicolaou KC, Ortiz A, Zhang H, Dagneau P, Lanver A, Jennings MP, Arseniyadis S, Faraoni R and Lizos DE (2010). Total Synthesis and Structural Revision of Vannusals A and B: Synthesis of the Originally Assigned Structure of Vannusal B. Journal of The American Chemical Society  vol. 132, (20) 7138-7152. 10.1021/ja100740t

ARSENIYADIS S and Spivey AC (2010). Amine, Alcohol & Phosphine Catalysts for Acyl Transfer Reactions. Asymmetric Organocatalysis  Springer Science & Business Media 

2009

Lebeuf R, Fe¿re¿zou I, Rossier J, Arseniyadis S and Cossy J (2009). Straightforward Synthesis of the Near-Infrared Fluorescent Voltage-Sensitive Dye RH1691 and Analogues Thereof. Organic Letters  vol. 11, (21) 4822-4825. 10.1021/ol901846g

Hoffman TJ, Dash J, Rigby JH, Arseniyadis S and Cossy J (2009). Enantioselective Organocatalytic Conjugate Reduction of ?-Azole-Containing ?,?-Unsaturated Aldehydes. Organic Letters  vol. 11, (13) 2756-2759. 10.1021/ol900893e

Bressy C, Bargiggia F, Guyonnet M, Arseniyadis S and Cossy J (2009). One-Pot Hydrosilylation-RCM-Protodesilylation: Application to the Synthesis of ?-Alkenyl ?,?-Unsaturated Lactones. Synlett  vol. 2009, (04) 565-568. 10.1055/s-0028-1087910

Sonawane R, Joolakanti S, Arseniyadis S and Cossy J (2009). Asymmetric Pentenylation of Aldehydes: A New Benchmark for the Preparation of Ethyl-Substituted Homoallylic Alcohol. Synlett  vol. 2009, (02) 213-216. 10.1055/s-0028-1087641

2008

Bressy C, Vors J-P, Hillebrand S, Arseniyadis S and Cossy J (2008). Asymmetric Total Synthesis of the Immunosuppressant (-)-Pironetin. Angewandte Chemie International Edition  vol. 47, (52) 10137-10140. 10.1002/anie.200802423

Moïse J, Sonawane R, Corsi C, Wendeborn S, Arseniyadis S and Cossy J (2008). Formal Synthesis of Leustroducsin B. Synlett  vol. 2008, (17) 2617-2620. 10.1055/s-0028-1083511

Gebauer J, Arseniyadis S and Cossy J (2008). Total Synthesis of Cystothiazole A by Microwave-Assisted Olefin Cross-Metathesis. European Journal of Organic Chemistry  vol. 2008, (16) 2701-2704. 10.1002/ejoc.200800203

Gebauer J, Arseniyadis S and Cossy J (2008). Facile Synthesis of the C1-C13 Fragment of Lyngbouilloside. Synlett  vol. 2008, (05) 712-714. 10.1055/s-2008-1042805

Hoffman TJ, Rigby JH, Arseniyadis S and Cossy J (2008). Synthesis of Vinyl-Functionalized Oxazoles by Olefin Cross-Metathesis. The Journal of Organic Chemistry  vol. 73, (6) 2400-2403. 10.1021/jo702305g

Sabot C, Subhash P, Valleix A, Arseniyadis S and Mioskowski C (2008). Nonenzymatic Kinetic Resolution of Amines in Ionic Liquids. Synlett  vol. 2008, (2) 268-272. 10.1055/s-2007-1000879

2007

Gebauer J, Arseniyadis S and Cossy J (2007). A Concise Total Synthesis of Melithiazole C ? Organic Letters  vol. 9, (17) 3425-3427. 10.1021/ol701459j

Altmann K-H, Pfeiffer B, Arseniyadis S, Pratt BA and Nicolaou KC (2007). The Chemistry and Biology of Epothilones?The Wheel Keeps Turning. Chemmedchem  vol. 2, (4) 396-423. 10.1002/cmdc.200600206

Moïse J, Arseniyadis S and Cossy J (2007). Cross-Metathesis between ?-Methylene-?-butyrolactone and Olefins:? A Dramatic Additive Effect. Organic Letters  vol. 9, (9) 1695-1698. 10.1021/ol0703940

Dash J, Arseniyadis S and Cossy J (2007). Synthesis of Vinyl-Functionalized Thiazoles by Cross-Metathesis and Tandem Stille Coupling/Cross-Metathesis. Advanced Synthesis & Catalysis  vol. 349, (1-2) 152-156. 10.1002/adsc.200600509

2006

Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A and Giannakakou P (2006). Molecular Design and Chemical Synthesis of a Highly Potent Epothilone. Chemmedchem  vol. 1, (1) 41-44. 10.1002/cmdc.200500056

Spivey AC, Arseniyadis S, Fekner T, Maddaford A and Leese DP (2006). Rapid, room-temperature acylative kinetic resolution of sec-alcohols using atropisomeric 4-aminopyridine/triphenylphosphine catalysis. Tetrahedron  vol. 62, (2-3) 295-301. 10.1016/j.tet.2005.08.124

2005

Arseniyadis S, Subhash PV, Valleix A, Mathew SP, Blackmond DG, Wagner A and Mioskowski C (2005). Tuning the Enantioselective N-Acetylation of Racemic Amines:? A Spectacular Salt Effect. Journal of The American Chemical Society  vol. 127, (17) 6138-6139. 10.1021/ja051302+

Arseniyadis S, Subhash PV, Valleix A, Wagner A and Mioskowski C (2005). Unprecedented, fully recyclable, solid-supported reagent for the kinetic resolution of racemic amines through enantioselective N-acetylation. Chemical Communications  (26) 3310-3310. 10.1039/b504200c

2004

Spivey AC and Arseniyadis S (2004). Nucleophilic Catalysis by 4-(Dialkylamino)pyridines Revisited?The Search for Optimal Reactivity and Selectivity. Angewandte Chemie International Edition  vol. 43, (41) 5436-5441. 10.1002/anie.200460373

Arseniyadis S, Valleix A, Wagner A and Mioskowski C (2004). Kinetic Resolution of Amines: A Highly Enantioselective and Chemoselective Acetylating Agent with a Unique Solvent-Induced Reversal of Stereoselectivity. Angewandte Chemie International Edition  vol. 43, (25) 3314-3317. 10.1002/anie.200453956

Arseniyadis S, Wagner A and Mioskowski C (2004). Resin-bound 4-phenyl-1,2-dihydroquinoline (DHQ): a new safety-catch linker for solid-phase organic synthesis (SPOS). Tetrahedron Letters  vol. 45, (10) 2251-2253. 10.1016/j.tetlet.2003.12.161

2002

Arseniyadis S, Wagner A and Mioskowski C (2002). A straightforward preparation of amino?polystyrene resin from Merrifield resin. Tetrahedron Letters  vol. 43, (52) 9717-9719. 10.1016/S0040-4039(02)02192-5

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